About: Molecular detection of respiratory pathogens among children aged younger than 5 years hospitalized with febrile acute respiratory infections: A prospective hospital‐based observational study in Niamey, Niger

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About: Molecular detection of respiratory pathogens among children aged younger than 5 years hospitalized with febrile acute respiratory infections: A prospective hospital‐based observational study in Niamey, Niger Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Molecular detection of respiratory pathogens among children aged younger than 5 years hospitalized with febrile acute respiratory infections: A prospective hospital‐based observational study in Niamey, Niger
Creator	Issa, Idi Lagare, Adamou Mamadou, Saidou Tempia, Stefano Testa, Jean Bassira Issaka, \| Dano, Dan Halima, \| Ibrahim, \| Mainassara, Boubacar Moumouni, Abdou Sani Ousmane, \|
source	Medline; PMC
abstract	BACKGROUND AND AIMS: In Niger, acute respiratory infections (ARIs) are the second most common cause of death in children aged younger than 5 years. However, the etiology of ARI is poorly understood in the country. This study aims to describe viral and bacterial infections among children aged younger than 5 years hospitalized with febrile ARI at two hospitals in Niamey, Niger's capital city, and the reported clinical procedures. METHODS: We conducted a prospective study among children aged younger than 5 years hospitalized with febrile ARI at two national hospitals in Niamey between January and December 2015. Clinical presentation and procedures during admission were documented using a standardized case investigation form. Nasopharyngeal specimens collected from each patient were tested for a panel of respiratory viruses and bacteria using the Fast Track Diagnostic 21 Plus kit. RESULTS: We enrolled and tested 638 children aged younger than 5 years, of whom 411 (64.4%) were aged younger than 1 year, and 15 (2.4%) died during the study period. Overall, 496/638 (77.7%) specimens tested positive for at least one respiratory virus or bacterium; of these, 195 (39.3%) tested positive for respiratory viruses, 126 (25.4%) tested positive for respiratory bacteria, and 175 (35.3%) tested positive for both respiratory viruses and bacteria. The predominant viruses detected were respiratory syncytial virus (RSV) (149/638; 23.3%), human parainfluenza virus (HPIV) types 1 to 4 (78/638; 12.2%), human rhinovirus (HRV) (62/638; 9.4%), human adenovirus (HAV) (60/638; 9.4%), and influenza virus (INF) (52/638; 8.1%). Streptococcus pneumoniae (249/638; 39.0%) was the most frequently detected bacterium, followed by Staphylococcus aureus (112/638; 12.2%) and Haemophilus influenzae type B (16/638; 2.5%). Chest X‐rays were performed at the discretion of the attending physician on 301 (47.2%) case patients. Of these patients, 231 (76.7%) had abnormal radiological findings. A total of 135/638 (21.2%) and 572/638 (89.7%) children received antibiotic treatment prior to admission and during admission, respectively. CONCLUSION: A high proportion of respiratory viruses was detected among children aged younger than 5 years with febrile ARI, raising concerns about excessive use of antibiotics in Niger.
has issue date	2019-10-11(xsd:dateTime)
bibo:doi	10.1002/hsr2.137
bibo:pmid	31768420
has license	cc-by
sha1sum (hex)	bad0e9f737316570c33138d5cc95cc233cd937ab
schema:url	https://doi.org/10.1002/hsr2.137
resource representing a document's title	Molecular detection of respiratory pathogens among children aged younger than 5 years hospitalized with febrile acute respiratory infections: A prospective hospital‐based observational study in Niamey, Niger
has PubMed Central identifier	PMC6869554
has PubMed identifier	31768420
schema:publication	Health Sci Rep
resource representing a document's body	covid:bad0e9f737316570c33138d5cc95cc233cd937ab#body_text
is schema:about of	named entity 'CHILDREN' named entity 'ACUTE RESPIRATORY INFECTIONS' named entity 'YOUNGER' named entity 'YEARS' named entity 'SECOND' named entity 'NIAMEY' named entity 'AGED' named entity 'BACTERIAL INFECTIONS' named entity 'CAUSE OF DEATH' named entity 'CAPITAL' named entity 'VIRAL AND' named entity 'ARI' named entity 'PROSPECTIVE' named entity 'BASED' named entity 'FEBRILE' named entity 'TO DESCRIBE' named entity 'COMMON' named entity 'NIGER' named entity 'OBSERVATIONAL STUDY' named entity 'HOSPITALIZED' named entity 'MOLECULAR' named entity 'RESPIRATORY PATHOGENS' named entity 'POORLY' named entity 'YEARS' named entity 'CHILDREN' named entity 'FEBRILE' named entity 'PROCEDURES' named entity 'HOSPITALIZED' named entity 'NIAMEY' named entity 'HOSPITALS' named entity 'AGED' named entity 'REPORTED' named entity 'STUDY' named entity 'COUNTRY' named entity 'CLINICAL' named entity 'CITY' named entity 'UNDERSTOOD' named entity '27S' named entity 'DETECTION' named entity 'NIGER' named entity 'ETIOLOGY' named entity 'YOUNGER' named entity 'HOSPITAL' named entity 'AIMS' named entity 'ACUTE RESPIRATORY INFECTIONS' covid:arg/bad0e9f737316570c33138d5cc95cc233cd937ab named entity 'Niger' named entity 'pathogens' named entity 'febrile' named entity 'acute respiratory infections' named entity 'febrile' named entity 'deaths among children' named entity 'dry season' named entity 'bacteria' named entity 'laboratory diagnosis' named entity 'child mortality' named entity 'meteorology' named entity 'Malaria' named entity 'plasmid' named entity 'young children' named entity 'healthcare systems' named entity 'empiric antibiotic therapy' named entity 'pathogen' named entity 'bacterial pathogens' named entity 'viruses' named entity 'nasal flaring' named entity 'College Station, Texas' named entity 'blood samples' named entity 'causality' named entity 'assess risk'

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