About: Respiratory epithelial cells as master communicators during viral infections

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Respiratory epithelial cells as master communicators during viral infections
Creator	Miura, Tanya
Source	Medline; PMC
abstract	PURPOSE OF REVIEW: Communication by epithelial cells during respiratory viral infections is critical in orchestrating effective anti-viral responses but also can lead to excessive inflammation. This review will evaluate studies that investigate how respiratory epithelial cells influence the behavior of immune cells and how epithelial cell/immune cell interactions contribute to antiviral responses and immunopathology outcomes. RECENT FINDINGS: Previous studies have characterized cytokine responses of virus-infected epithelial cells. More recent studies have carefully demonstrated the effects of these cytokines on cellular behaviors within the infected lung. Infected epithelial cells release exosomes that specifically regulate responses of monocytes and neighboring epithelial cells without promoting spread of virus. In contrast, rhinovirus-infected cells induce monocytes to upregulate expression of the viral receptor, promoting spread of the virus to alternate cell types. The precise alteration of PDL expression on infected epithelial cells has been shown to switch between inhibition and activation of antiviral responses. SUMMARY: These studies have more precisely defined the interactions between epithelial and immune cells during viral infections. This level of understanding is critical for the development of novel therapeutic strategies that promote effective antiviral responses or epithelial repair, or inhibit damaging inflammatory responses during severe respiratory viral infections.
has issue date	2019-02-13(xsd:dateTime)
bibo:doi	10.1007/s40588-019-0111-8
bibo:pmid	31592409
has license	green-oa
sha1sum (hex)	ba71e2e598bd8b6c3c9d825269600523afed2228
schema:url	https://doi.org/10.1007/s40588-019-0111-8
resource representing a document's title	Respiratory epithelial cells as master communicators during viral infections
has PubMed Central identifier	PMC6779166
has PubMed identifier	31592409
schema:publication	Current Clinical Microbiology Reports
resource representing a document's body	covid:ba71e2e598bd8b6c3c9d825269600523afed2228#body_text
is schema:about of	named entity 'RESPIRATORY' named entity 'EPITHELIAL CELLS' named entity 'behavior' named entity 'responses' named entity 'Infections' named entity 'SECTION' named entity 'EDITOR' named entity 'VIRAL INFECTIONS' named entity 'NICOLA' named entity 'INFLUENCE' named entity 'INTERACTIONS' named entity 'BUT' named entity 'CONTRIBUTE ' named entity 'IMMUNE CELLS' named entity 'EFFECTIVE' named entity 'EPITHELIAL CELL' named entity 'PURPOSE' named entity 'RESPONSES' named entity 'BEHAVIOR' named entity 'INVESTIGATE' named entity 'IMMUNOPATHOLOGY' named entity 'MASTER' named entity 'VIROLOGY' named entity '28A' named entity 'EPITHELIAL CELLS' named entity 'EXCESSIVE' named entity 'LEAD' named entity 'REVIEW' named entity 'HOW' named entity 'EVALUATE' named entity 'CELL' named entity 'STUDIES' named entity 'CRITICAL' named entity 'RESPIRATORY' named entity 'COMMUNICATION' named entity 'VIRAL INFECTIONS' named entity 'ANTIVIRAL' named entity 'INFLAMMATION' named entity 'OUTCOMES' named entity 'orchestrating' named entity 'evaluate' named entity 'viral infections' named entity 'Communication' named entity 'immunopathology' named entity 'epithelial cells' named entity 'Respiratory' named entity 'epithelial cell' named entity 'antiviral' named entity 'immunopathology' named entity 'immune cell' named entity 'Epithelial Cells' named entity 'epithelial cells' named entity 'cell types' named entity 'epithelial cells' named entity 'chemokines' named entity 'IFN' named entity 'neutrophilic' named entity 'RSV' named entity 'epithelial cell' named entity 'antiviral' named entity 'mice' named entity 'rhinovirus' named entity 'IgA' named entity 'eosinophils' named entity 'gene expression' named entity 'IL-1β' named entity 'chemokine' named entity 'vaccine strain' named entity 'neutrophil' named entity 'Mouse models' named entity 'coronavirus HKU1' named entity 'viral infection' named entity 'epithelial cells' named entity 'TNF-α' named entity 'respiratory tract' named entity 'lungs' named entity 'RSV' named entity 'epithelial cells' named entity 'IAV' named entity 'IFN' named entity 'infection'

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