About: Induction of monocyte procoagulant activity by murine hepatitis virus type 3 parallels disease susceptibility in mice

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About: Induction of monocyte procoagulant activity by murine hepatitis virus type 3 parallels disease susceptibility in mice Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Induction of monocyte procoagulant activity by murine hepatitis virus type 3 parallels disease susceptibility in mice
Creator	Edgington, T Leibowitz, ~ Levy, G
Source	PMC
abstract	The in vitro induction of procoagulant activity (PCA) in murine peripheral blood mononuclear cells (PBM) by murine hepatitis virus type 3 (MHV-3) correlates with the disease susceptibility in three strains of mice. PBM from BALB/c mice, a strain in which MHV-3 infection results in fatal acute fulminant hepatitis, responds to the virus with a robust PCA response, whereas PBM from C3H/St mice, a strain which develops mild acute hepatitis followed by chronic hepatitis, only exhibit a modest PCA response. In contrast, PBM from A/J mice, a strain fully resistant to MHV-3, generate no increase in PCA above control levels. The induction phase of MHV-3 PCA is rapid, with an increase within 1-1.5 h, with maximum activity at 18h, and it precedes MHV-3 replication in either 17 CL1 cells, a fully permissive cell line, or in monocytes from these strains of mice. The PCA response of BALB/c PBM exceeds the response to any other known stimulus. No induction occurs upon direct stimulation of monocytes by MHV-3, but in the presence of lymphocyte collaboration, the PCA response is observed first at a lymphocyte:monocyte ratio of 2:1 and reaches a maximum as the lymphocyte:monocyte ratio approaches 4:1. This response appears to provide a functional marker for susceptibility to MHV-3 infection in inbred strains of mice and could be important in the pathogenesis of MHV-3-induced disease.
has issue date	1981-10-01(xsd:dateTime)
bibo:pmid	6270227
has license	cc-by-nc-sa
sha1sum (hex)	ba4ec5cbbb67efa5caafb7f69b6591a83d59d3a7
resource representing a document's title	Induction of monocyte procoagulant activity by murine hepatitis virus type 3 parallels disease susceptibility in mice
has PubMed Central identifier	PMC2186492
has PubMed identifier	6270227
schema:publication	J Exp Med
resource representing a document's body	covid:ba4ec5cbbb67efa5caafb7f69b6591a83d59d3a7#body_text
is schema:about of	named entity 'MICE' named entity 'PROCOAGULANT ACTIVITY' named entity 'VIRUS TYPE' named entity 'MONOCYTE' named entity 'INDUCTION' named entity 'TYPE 3' named entity 'DISEASE SUSCEPTIBILITY' named entity 'MURINE HEPATITIS VIRUS' named entity 'PROCOAGULANT' named entity 'HEPATITIS VIRUS' named entity 'MONOCYTE' named entity 'MURINE' named entity 'monocytes' named entity 'MOI' named entity 'lymphocyte' named entity 'multiplicity of infection' named entity 'serologically' named entity 'macrophage' named entity 'LPS' named entity 'hepatitis virus' named entity 'BALB' named entity 'human plasma' named entity 'log-log plot' named entity 'virus' named entity 'LPS' named entity 'tissue factor' named entity 'trypan blue' named entity 'virus' named entity 'eclipse phase' named entity 'lymphocytes' named entity 'monocytes' named entity 'acute hepatitis' named entity 'lymphocytes' named entity 'lymphoreticular' named entity 'peripheral blood mononuclear cells' named entity 'DMEM' named entity 'Md.' named entity 'LPS' named entity 'monocytes' named entity 'antigen' named entity 'plaque assay' named entity 'BALB' named entity 'Monocytes' named entity 'Mo.' named entity 'peritoneal' named entity 'helper cells' named entity 'hepatitis' named entity 'antigen-antibody complexes' named entity 'immune response' named entity 'endotoxin' named entity 'monocyte' named entity 'human plasma' named entity 'MOI' named entity 'hepatotropic' named entity 'lymphocytes' named entity 'hepatitis' named entity 'BALB' named entity 'monocyte' named entity 'serotype' named entity 'virus' named entity 'monocytes' named entity 'infection' named entity 'monocyte' named entity 'lymphocytes' named entity 'Miami' named entity 'mouse strains' named entity 'procoagulant' named entity 'fulminant hepatitis' named entity 'virus' named entity 'response to stimuli' named entity 'sonication' named entity 'monocyte' named entity 'chronic disease' named entity 'BALB/c' named entity 'LPS' named entity 'monocytes' named entity 'Scripps Clinic' named entity 'esterase' named entity 'humoral' named entity 'BALB' named entity 'lectins'

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