About: Nidovirus RNA polymerases: Complex enzymes handling exceptional RNA genomes

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Nidovirus RNA polymerases: Complex enzymes handling exceptional RNA genomes
Creator	Snijder, Eric Posthuma, Clara Te Velthuis, Aartjan
Source	Elsevier; Medline; PMC
abstract	Abstract Coronaviruses and arteriviruses are distantly related human and animal pathogens that belong to the order Nidovirales. Nidoviruses are characterized by their polycistronic plus-stranded RNA genome, the production of subgenomic mRNAs and the conservation of a specific array of replicase domains, including key RNA-synthesizing enzymes. Coronaviruses (26–34 kilobases) have the largest known RNA genomes and their replication presumably requires a processive RNA-dependent RNA polymerase (RdRp) and enzymatic functions that suppress the consequences of the typically high error rate of viral RdRps. The arteriviruses have significantly smaller genomes and form an intriguing package with the coronaviruses to analyse viral RdRp evolution and function. The RdRp domain of nidoviruses resides in a cleavage product of the replicase polyprotein named non-structural protein (nsp) 12 in coronaviruses and nsp9 in arteriviruses. In all nidoviruses, the C-terminal RdRp domain is linked to a conserved N-terminal domain, which has been coined NiRAN (nidovirus RdRp-associated nucleotidyl transferase). Although no structural information is available, the functional characterization of the nidovirus RdRp and the larger enzyme complex of which it is part, has progressed significantly over the past decade. In coronaviruses several smaller, non-enzymatic nsps were characterized that direct RdRp function, while a 3′-to-5′ exoribonuclease activity in nsp14 was implicated in fidelity. In arteriviruses, the nsp1 subunit was found to maintain the balance between genome replication and subgenomic mRNA production. Understanding RdRp behaviour and interactions during RNA synthesis and subsequent processing will be key to rationalising the evolutionary success of nidoviruses and the development of antiviral strategies.
has issue date	2017-04-15(xsd:dateTime)
bibo:doi	10.1016/j.virusres.2017.01.023
bibo:pmid	28174054
has license	els-covid
sha1sum (hex)	ba334a8f734285257878e0df4e64a6131818d0c6
schema:url	https://doi.org/10.1016/j.virusres.2017.01.023
resource representing a document's title	Nidovirus RNA polymerases: Complex enzymes handling exceptional RNA genomes
has PubMed Central identifier	PMC7114556
has PubMed identifier	28174054
schema:publication	Virus Research
resource representing a document's body	covid:ba334a8f734285257878e0df4e64a6131818d0c6#body_text
is schema:about of	named entity 'COMPLEX' named entity 'analyse' named entity 'pathogens' named entity 'progressed' named entity 'mRNAs' named entity 'evolution' named entity 'RdRp' named entity 'genomes' named entity 'genomes' named entity 'functional' named entity 'exceptional' named entity 'Complex' named entity 'POLYMERASES' named entity 'FOUND' named entity 'NSP1' named entity 'HAVE' named entity 'C-TERMINAL' named entity 'TRANSFERASE' named entity 'ARTERIVIRUSES' named entity 'RNA-DEPENDENT RNA POLYMERASE' named entity 'BALANCE' named entity 'LARGEST' named entity 'DISTANTLY' named entity 'FUNCTIONS' named entity 'ENZYMES' named entity 'NON-' named entity 'PRODUCT' named entity 'RNA SYNTHESIS' named entity 'BEHAVIOUR' named entity 'SUPPRESS' named entity 'POLYPROTEIN' named entity 'MRNA' named entity 'FIDELITY' named entity 'PROGRESSED' named entity 'MRNAS' named entity 'CONSERVED' named entity 'SUCCESS' named entity 'GENOMES' named entity 'REPLICATION' named entity 'UNDERSTANDING' named entity 'CONSEQUENCES' named entity 'ORDER NIDOVIRALES' named entity 'AVAILABLE' named entity 'ERROR' named entity 'STRUCTURAL' named entity 'LARGER' named entity 'FUNCTIONAL' named entity 'EXORIBONUCLEASE ACTIVITY' named entity 'ENZYMATIC' named entity 'NSPS' named entity 'VIRAL' named entity 'CHARACTERIZATION' named entity 'SUBSEQUENT' named entity 'GENOMES' named entity 'ENZYMES' named entity 'REPLICASE' named entity 'INTERACTIONS' named entity 'HANDLING' named entity 'N-TERMINAL ' named entity 'THEIR' named entity 'KNOWN' named entity 'RNA' named entity 'CORONAVIRUSES' named entity 'POLYCISTRONIC' named entity 'STRATEGIES' named entity 'EVOLUTION' named entity 'RATE' named entity 'TO MAINTAIN' named entity 'PRODUCTION' named entity 'ENZYME COMPLEX' named entity 'ASSOCIATED' named entity 'PACKAGE' named entity 'FUNCTION' named entity 'KEY' named entity 'DOMAIN' named entity 'SUBUNIT' named entity 'DECADE' named entity 'RDRP' named entity 'CONSERVATION'

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