About: Due to the current COVID-19 situation caused by the spread of the new SARS-Cov-2 coronavirus, new alternative materials with antiviral activity are encouraged to be fabricated by the World Health Organization for present and future pandemics. Previous studies of low-cost alginate-based nanocomposite films produced with very low amounts (0.1% w/w) of carbon nanomaterials such as graphene oxide (GO) or carbon nanofibers (CNFs) have shown very low transparency reduction, enhanced mechanical performance, improved water diffusion and wettability, and similar biological properties than neat alginate in terms of cell adhesion and non-cytotoxicity. However, only the nanocomposite containing CNFs have shown antibacterial activity. Herein, the antiviral properties of these nanocomposite biomaterials are explored for the first time in literature using a double-stranded DNA viral model. The results of this study showed that neat calcium alginate films possess antiviral activity and the incorporation of that low percentage of CNFs significantly enhanced its antiviral action from ~55.6% to 96.33% inhibition after 48 hours. Nevertheless, the addition of this minuscule amount of GO did not improve the antiviral activity of calcium alginate. Nonetheless, both antiviral composite biomaterials possess excellent physical and biological properties with great potential in biomedical applications.

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About: Due to the current COVID-19 situation caused by the spread of the new SARS-Cov-2 coronavirus, new alternative materials with antiviral activity are encouraged to be fabricated by the World Health Organization for present and future pandemics. Previous studies of low-cost alginate-based nanocomposite films produced with very low amounts (0.1% w/w) of carbon nanomaterials such as graphene oxide (GO) or carbon nanofibers (CNFs) have shown very low transparency reduction, enhanced mechanical performance, improved water diffusion and wettability, and similar biological properties than neat alginate in terms of cell adhesion and non-cytotoxicity. However, only the nanocomposite containing CNFs have shown antibacterial activity. Herein, the antiviral properties of these nanocomposite biomaterials are explored for the first time in literature using a double-stranded DNA viral model. The results of this study showed that neat calcium alginate films possess antiviral activity and the incorporation of that low percentage of CNFs significantly enhanced its antiviral action from ~55.6% to 96.33% inhibition after 48 hours. Nevertheless, the addition of this minuscule amount of GO did not improve the antiviral activity of calcium alginate. Nonetheless, both antiviral composite biomaterials possess excellent physical and biological properties with great potential in biomedical applications. Goto Sponge NotDistinct Permalink

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type	abstract
value	Due to the current COVID-19 situation caused by the spread of the new SARS-Cov-2 coronavirus, new alternative materials with antiviral activity are encouraged to be fabricated by the World Health Organization for present and future pandemics. Previous studies of low-cost alginate-based nanocomposite films produced with very low amounts (0.1% w/w) of carbon nanomaterials such as graphene oxide (GO) or carbon nanofibers (CNFs) have shown very low transparency reduction, enhanced mechanical performance, improved water diffusion and wettability, and similar biological properties than neat alginate in terms of cell adhesion and non-cytotoxicity. However, only the nanocomposite containing CNFs have shown antibacterial activity. Herein, the antiviral properties of these nanocomposite biomaterials are explored for the first time in literature using a double-stranded DNA viral model. The results of this study showed that neat calcium alginate films possess antiviral activity and the incorporation of that low percentage of CNFs significantly enhanced its antiviral action from ~55.6% to 96.33% inhibition after 48 hours. Nevertheless, the addition of this minuscule amount of GO did not improve the antiviral activity of calcium alginate. Nonetheless, both antiviral composite biomaterials possess excellent physical and biological properties with great potential in biomedical applications.
subject	Antivirals Biocides Organizations established in 1948 Copolymers Brown algae
part of	Low-cost alginate-based nanocomposite films showed high antiviral activity
is abstract of	Low-cost alginate-based nanocomposite films showed high antiviral activity
is hasSource of	covid:ann/target/4a8c8e414e1e0c115e8ea23e1460873ce1cc9192 covid:ann/target/5c0287e2b1f554ef09d77a4027f3c50d785f593c covid:ann/target/fac470903bd7f50044816b7a730d92203be6e804 covid:ann/target/023b04ef57cf0b6276ae41505c005acbb9ebefdf covid:ann/target/196dabfabc78c248fda7f1883ea8e2c82fd2a63b »more»

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