About: Age-Related differences in immunological responses to SARS-CoV-2

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Age-Related differences in immunological responses to SARS-CoV-2
Creator	Kang, Hui Tambyah, Paul Kang, Wong, Yin Hui, Alicia Lau, Hui Loo, Ling Su, Lydia Tham, Elizabeth Tham, Huiwen Xiu, Evelyn Yi, Alicia
Source	Elsevier; PMC
abstract	There is a striking age-related disparity in the prevalence and severity of SARS-CoV-2 induced COVID-19 infections, which might be explained by age-dependent immunological mechanisms. These include age-related physiological differences in immunological responses, cross-neutralizing antibodies, differences in levels and binding affinity of ACE-2, the SARS-CoV-2 target receptor; antibody dependent enhancement (ADE) in adults manifesting with an over-exuberant systemic inflammation in response to infection; and the increased likelihood of co-morbidities in adults and the elderly. Emerging immunological phenomena such as PMIS-TS (Paediatric Multi-System Inflammatory Disorder Temporally associated with SARS-CoV-2) or MIS-C (Multisystem Inflammatory Syndrome in Children are now being observed, though the underlying mechanisms are still unclear. Understanding the mechanisms through which pediatric patients are protected from severe novel coronaviruses infections will provide critical clues to the pathophysiology of COVID-19 infection and inform future therapeutic and prophylactic interventions. Asymptomatic carriage in children may have major public health implications which impact on social and healthcare policies on screening and isolation practices, school reopening and safe distancing requirements in the community.
has issue date	2020-08-27(xsd:dateTime)
bibo:doi	10.1016/j.jaip.2020.08.026
has license	els-covid
sha1sum (hex)	ba0a2162fa7a244f2227ff466ba74d485fd04acb
schema:url	https://doi.org/10.1016/j.jaip.2020.08.026
resource representing a document's title	Age-Related differences in immunological responses to SARS-CoV-2
has PubMed Central identifier	PMC7450283
schema:publication	J Allergy Clin Immunol Pract
resource representing a document's body	covid:ba0a2162fa7a244f2227ff466ba74d485fd04acb#body_text
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