About: Polyvalent DNA Vaccines Expressing HA Antigens of H5N1 Influenza Viruses with an Optimized Leader Sequence Elicit Cross-Protective Antibody Responses

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About: Polyvalent DNA Vaccines Expressing HA Antigens of H5N1 Influenza Viruses with an Optimized Leader Sequence Elicit Cross-Protective Antibody Responses Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Polyvalent DNA Vaccines Expressing HA Antigens of H5N1 Influenza Viruses with an Optimized Leader Sequence Elicit Cross-Protective Antibody Responses
Creator	Wang, S Zhang, L Zhang, C Hackett, A Jia, N
Source	PMC
abstract	Highly pathogenic avian influenza A (HPAI) H5N1 viruses are circulating among poultry populations in parts of Asia, Africa, and the Middle East, and have caused human infections with a high mortality rate. H5 subtype hemagglutinin (HA) has evolved into phylogenetically distinct clades and subclades based on viruses isolated from various avian species. Since 1997, humans have been infected by HPAI H5N1 viruses from several clades. It is, therefore, important to develop strategies to produce protective antibody responses against H5N1 viruses from multiple clades or antigenic groups. In the current study, we optimized the signal peptide design of DNA vaccines expressing HA antigens from H5N1 viruses. Cross reactivity analysis using sera from immunized rabbits showed that antibody responses elicited by a polyvalent formulation, including HA antigens from different clades, was able to elicit broad protective antibody responses against multiple key representative H5N1 viruses across different clades. Data presented in this report support the development of a polyvalent DNA vaccine strategy against the threat of a potential H5N1 influenza pandemic.
has issue date	2011-12-21(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0028757
bibo:pmid	22205966
has license	cc-by
sha1sum (hex)	ba03011c4b23d19642ea33554a6789895558ad97
schema:url	https://doi.org/10.1371/journal.pone.0028757
resource representing a document's title	Polyvalent DNA Vaccines Expressing HA Antigens of H5N1 Influenza Viruses with an Optimized Leader Sequence Elicit Cross-Protective Antibody Responses
has PubMed Central identifier	PMC3244406
has PubMed identifier	22205966
schema:publication	PLoS One
resource representing a document's body	covid:ba03011c4b23d19642ea33554a6789895558ad97#body_text
is schema:about of	named entity 'Since' named entity 'Africa' named entity 'viruses' named entity 'H5N1' named entity 'influenza pandemic' named entity 'Asia' named entity 'humans' named entity 'CHINA' named entity 'SUBTYPE' named entity 'INFECTIONS' named entity 'CAUSED' named entity 'STRATEGIES' named entity 'MULTIPLE' named entity 'PARTS' named entity 'CIRCULATING' named entity 'SPECIES' named entity 'BROAD' named entity 'TO PRODUCE' named entity 'PRESENTED' named entity 'EVOLVED' named entity 'ANTIBODY' named entity 'BASED' named entity 'HIGHLY PATHOGENIC AVIAN INFLUENZA' named entity 'KEY' named entity 'CURRENT' named entity '1997' named entity 'SIGNAL PEPTIDE' named entity 'STUDY' named entity 'AVIAN' named entity 'HEMAGGLUTININ' named entity 'ELICITED BY' named entity 'HUMANS' named entity 'INCLUDING' named entity 'HUMAN' named entity 'POPULATIONS' named entity 'THREAT' named entity 'ASIA' named entity 'DIFFERENT' named entity 'ISOLATED' named entity 'HPAI' named entity 'RABBITS' named entity 'IMMUNIZED' named entity 'CROSS REACTIVITY' named entity 'DNA VACCINE' named entity 'SUPPORT' named entity 'IMPORTANT' named entity 'SERA' named entity 'H5N1 INFLUENZA' named entity 'VARIOUS' named entity 'INFECTION' named entity 'POULTRY' named entity 'DEVELOPMENT' named entity 'REPORT' named entity 'MORTALITY RATE' named entity 'POTENTIAL' named entity 'ANTIGENS' named entity 'VIRUSES' named entity 'HAVE' named entity 'REPRESENTATIVE' named entity 'DATA' named entity 'DNA VACCINES' named entity 'MIDDLE EAST' named entity 'ACROSS' named entity 'NATIONAL' named entity 'SPECIAL' named entity 'DISEASES' named entity 'GRANT' named entity 'USING' named entity 'H5N1' named entity 'AFRICA' named entity 'HIGH' named entity 'RESPONSES' named entity 'DISTINCT' named entity 'FUNDING' named entity 'FOUNDATION' named entity 'ANALYSIS' named entity 'INFECTED'

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