About: Inferring Infection Patterns Based on a Connectivity Map of Host Transcriptional Responses

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Inferring Infection Patterns Based on a Connectivity Map of Host Transcriptional Responses
Creator	Li, Fei Liu, Yang Bai, Hui Bo, Xiaochen Cui, Xiuliang Han, Lu He, Haochen Wang, Shengqi Xie, Dafei Zheng, Xiaofei
source	Medline; PMC
abstract	Host responses to infections represent an important pathogenicity determiner, and delineation of host responses can elucidate pathogenesis processes and inform the development of anti-infection therapies. Low cost, high throughput, easy quantitation, and rich descriptions have made gene expression profiling generated by DNA microarrays an optimal approach for describing host transcriptional responses (HTRs). However, efforts to characterize the landscape of HTRs to diverse pathogens are far from offering a comprehensive view. Here, we developed an HTR Connectivity Map based on systematic assessment of pairwise similarities of HTRs to 50 clinically important human pathogens using 1353 gene-expression profiles generated from >60 human cells/tissues. These 50 pathogens were further partitioned into eight robust “HTR communities” (i.e., groups with more consensus internal HTR similarities). These communities showed enrichment in specific infection attributes and differential gene expression patterns. Using query signatures of HTRs to external pathogens, we demonstrated four distinct modes of HTR associations among different pathogens types/class, and validated the reliability of the HTR community divisions for differentiating and categorizing pathogens from a host-oriented perspective. These findings provide a first-generation HTR Connectivity Map of 50 diverse pathogens, and demonstrate the potential for using annotated HTR community to detect functional associations among infectious pathogens.
has issue date	2015-10-28(xsd:dateTime)
bibo:doi	10.1038/srep15820
bibo:pmid	26508266
has license	cc-by
sha1sum (hex)	b9a74f1f03a9b75351badb02e13448d1f65f7ed8
schema:url	https://doi.org/10.1038/srep15820
resource representing a document's title	Inferring Infection Patterns Based on a Connectivity Map of Host Transcriptional Responses
has PubMed Central identifier	PMC4623713
has PubMed identifier	26508266
schema:publication	Sci Rep
resource representing a document's body	covid:b9a74f1f03a9b75351badb02e13448d1f65f7ed8#body_text
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