About: Molecular Basis of the Differentiation and Function of Virus Specific Follicular Helper CD4(+) T Cells

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About: Molecular Basis of the Differentiation and Function of Virus Specific Follicular Helper CD4(+) T Cells Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Molecular Basis of the Differentiation and Function of Virus Specific Follicular Helper CD4(+) T Cells
Creator	Villinger, Francois Hu, Jianjun Huang, Qizhao Tang, Jianfang Xu, Lifan Ye, Lilin Cicalese, Maria
Source	Medline; PMC
abstract	During viral infection, virus-specific follicular helper T cells provide important help to cognate B cells for their survival, consecutive proliferation and mutation and eventual differentiation into memory B cells and antibody-secreting plasma cells. Similar to Tfh cells generated in other conditions, the differentiation of virus-specific Tfh cells can also be characterized as a process involved multiple factors and stages, however, which also exhibits distinct features. Here, we mainly focus on the current understanding of Tfh fate commitment, functional maturation, lineage maintenance and memory transition and formation in the context of viral infection.
has issue date	2019-02-15(xsd:dateTime)
bibo:doi	10.3389/fimmu.2019.00249
bibo:pmid	30828337
has license	cc-by
sha1sum (hex)	b952307f004f6feab9b3ae2cbee6d14f28ef9b4d
schema:url	https://doi.org/10.3389/fimmu.2019.00249
resource representing a document's title	Molecular Basis of the Differentiation and Function of Virus Specific Follicular Helper CD4(+) T Cells
has PubMed Central identifier	PMC6384271
has PubMed identifier	30828337
schema:publication	Front Immunol
resource representing a document's body	covid:b952307f004f6feab9b3ae2cbee6d14f28ef9b4d#body_text
is schema:about of	named entity 'VIRUS' named entity 'UNDERSTANDING' named entity 'THEIR' named entity 'HERE' named entity 'FATE' named entity 'EXHIBITS' named entity 'TRANSITION' named entity 'TFH' named entity 'GENERATED' named entity 'MUTATION' named entity 'CURRENT' named entity 'INVOLVED' named entity 'IMPORTANT HELP' named entity 'MULTIPLE' named entity 'CONSECUTIVE' named entity 'MEMORY' named entity 'B CELLS' named entity 'MEMORY B CELLS' named entity 'CD4' named entity 'cognate' named entity 'proliferation' named entity 'DIFFERENTIATION' named entity 'PLASMA CELLS' named entity 'PROCESS' named entity 'LINEAGE' named entity 'SPECIFIC' named entity 'FOLLICULAR' named entity 'T CELLS' named entity 'DIFFERENTIATION' named entity 'VIRUS' named entity 'MOLECULAR BASIS' named entity 'CONDITIONS' named entity 'TFH CELLS' named entity 'SECRETING' named entity 'MAINTENANCE' named entity 'COMMITMENT' named entity 'FOLLICULAR' named entity 'SURVIVAL' named entity 'VIRAL INFECTION' named entity 'CHARACTERIZED' named entity 'MATURATION' named entity 'FEATURES' named entity 'CONTEXT' named entity 'FUNCTION' named entity 'SIMILAR' named entity 'FUNCTIONAL' named entity 'FOCUS' named entity 'STAGES' named entity 'HELPER T CELLS' named entity 'SPECIFIC' named entity 'DISTINCT' named entity 'PROLIFERATION' named entity 'FORMATION' named entity 'PROVIDE' named entity 'ANTIBODY' named entity 'B cells' named entity 'B cells' named entity 'fate' named entity 'T Cells' named entity 'Molecular' named entity 'plasma cells' named entity 'mutation' named entity 'Tfh' named entity 'helper T cells' named entity 'Virus' named entity 'lymph node' named entity 'follicles' named entity 'memory B cell' named entity 'viral infection' named entity 'co-stimulatory molecules' named entity 'LCMV' named entity 'Tfh' named entity 'DCs' named entity 'critical role' named entity 'CXCR5'

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