About: Transcriptome analysis of chicken kidney tissues following coronavirus avian infectious bronchitis virus infection

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Transcriptome analysis of chicken kidney tissues following coronavirus avian infectious bronchitis virus infection
Creator	Han, Zongxi Kong, Xiangang Liu, Shengwang Liu, Xiaoli Shao, Yuhao Cong, Feng
Source	Medline; PMC
abstract	BACKGROUND: Infectious bronchitis virus (IBV), a prototype of the Coronaviridae family, is an economically important causative agent of infectious bronchitis in chickens and causes an acute and highly contagious upper respiratory tract infections that may lead to nephritis. However, the molecular antiviral mechanisms of chickens to IBV infection remain poorly understood. In this study, we conducted global gene expression profiling of chicken kidney tissue after nephropathogenic IBV infection to better understand the interactions between host and virus. RESULTS: IBV infection contributed to differential expression of 1777 genes, of which 876 were up-regulated and 901 down-regulated in the kidney compared to those of control chickens and 103 associated with immune and inflammatory responses may play important roles in the host defense response during IBV infection. Twelve of the altered immune-related genes were confirmed by real-time RT-PCR. Gene ontology category, KEGG pathway, and gene interaction networks (STRING analysis) were analyzed to identify relationships among differentially expressed genes involved in signal transduction, cell adhesion, immune responses, apoptosis regulation, positive regulation of the I-kappaB kinase/NF-kappaB cascade and response to cytokine stimulus. Most of these genes were related and formed a large network, in which IL6, STAT1, MYD88, IRF1 and NFKB2 were key genes. CONCLUSIONS: Our results provided comprehensive knowledge regarding the host transcriptional response to IBV infection in chicken kidney tissues, thereby providing insight into IBV pathogenesis, particularly the involvement of innate immune pathway genes associated with IBV infection.
has issue date	2013-10-30(xsd:dateTime)
bibo:doi	10.1186/1471-2164-14-743
bibo:pmid	24168272
has license	cc-by
sha1sum (hex)	b94abc8c5e511d49e02cc4175cccc27629f5ee76
schema:url	https://doi.org/10.1186/1471-2164-14-743
resource representing a document's title	Transcriptome analysis of chicken kidney tissues following coronavirus avian infectious bronchitis virus infection
has PubMed Central identifier	PMC3870970
has PubMed identifier	24168272
schema:publication	BMC Genomics
resource representing a document's body	covid:b94abc8c5e511d49e02cc4175cccc27629f5ee76#body_text
is schema:about of	named entity 'CHICKEN' named entity 'expressed genes' named entity 'defense response' named entity 'chickens' named entity 'networks' named entity 'kidney' named entity 'genes' named entity 'STAT1' named entity 'VIRUS INFECTION' named entity 'ALTERED' named entity 'APOPTOSIS' named entity 'IMMUNE' named entity 'COMPARED' named entity 'NEPHRITIS' named entity 'POSITIVE REGULATION' named entity 'ASSOCIATED WITH' named entity 'I-KAPPAB' named entity '2C CELL' named entity 'IL6' named entity 'NETWORK' named entity 'GENES' named entity 'ACUTE' named entity 'HIGHLY' named entity 'ECONOMICALLY IMPORTANT' named entity 'REGULATION' named entity 'ANTIVIRAL' named entity '1777' named entity 'PATHWAY' named entity 'GENE EXPRESSION PROFILING' named entity 'IMMUNE RESPONSES' named entity 'UNDERSTAND' named entity 'LARGE' named entity 'DIFFERENTIAL EXPRESSION' named entity 'THESE' named entity 'NETWORKS' named entity 'CHICKENS' named entity 'MOST OF' named entity 'CELL ADHESION' named entity 'LEAD' named entity 'HOST' named entity 'MECHANISMS' named entity 'CONFIRMED BY' named entity 'INFLAMMATORY RESPONSES' named entity 'STUDY' named entity 'GENE ONTOLOGY' named entity 'UNDERSTOOD' named entity 'CONTROL' named entity 'CATEGORY' named entity 'CORONAVIRUS' named entity 'AVIAN INFECTIOUS BRONCHITIS VIRUS' named entity 'DOWN-REGULATED' named entity 'HOST DEFENSE' named entity 'ANALYZED' named entity 'INVOLVED' named entity 'IRF1' named entity 'CORONAVIRIDAE' named entity 'POORLY' named entity '876' named entity 'TISSUE' named entity 'CASCADE' named entity 'RESULTS' named entity 'TISSUES' named entity 'PLAY' named entity 'GLOBAL' named entity 'KIDNEY' named entity 'TRANSCRIPTOME ANALYSIS' named entity 'KEY' named entity 'CHICKEN' named entity 'CAUSATIVE AGENT' named entity 'UPPER RESPIRATORY TRACT INFECTIONS' named entity 'MOLECULAR' named entity 'SIGNAL TRANSDUCTION' named entity 'IMPORTANT' named entity 'KIDNEY' named entity 'DEFENSE RESPONSE' named entity 'MYD88'

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