About: Using Clinical Research Networks to Assess Severity of an Emerging Influenza Pandemic

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Using Clinical Research Networks to Assess Severity of an Emerging Influenza Pandemic Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Using Clinical Research Networks to Assess Severity of an Emerging Influenza Pandemic
Creator	Simonsen, Lone Lynfield, Ruth Davey, Richard Lundgren, Jens Wentworth, Deborah Carey, Dianne Cozzi-Lepri, Al Higgs, Elizabeth Lane, Cliff Losso, Marcelo Morales, Kathleen Pett, Sarah Weckx, Jozef Dwyer, Dominic Taylor, Robert Glesby, Marshall
Source	Medline; PMC
abstract	BACKGROUND: Early clinical severity assessments during the 2009 influenza A H1N1 pandemic (pH1N1) overestimated clinical severity due to selection bias and other factors. We retrospectively investigated how to use data from the International Network for Strategic Initiatives in Global HIV Trials, a global clinical influenza research network, to make more accurate case fatality ratio (CFR) estimates early in a future pandemic, an essential part of pandemic response. METHODS: We estimated the CFR of medically attended influenza (CFR(MA)) as the product of probability of hospitalization given confirmed outpatient influenza and the probability of death given hospitalization with confirmed influenza for the pandemic (2009–2011) and post-pandemic (2012–2015) periods. We used literature survey results on health-seeking behavior to convert that estimate to CFR among all infected persons (CFR(AR)). RESULTS: During the pandemic period, 5.0% (3.1%–6.9%) of 561 pH1N1-positive outpatients were hospitalized. Of 282 pH1N1-positive inpatients, 8.5% (5.7%–12.6%) died. CFR(MA) for pH1N1 was 0.4% (0.2%–0.6%) in the pandemic period 2009–2011 but declined 5-fold in young adults during the post-pandemic period compared to the level of seasonal influenza in the post-pandemic period 2012–2015. CFR for influenza-negative patients did not change over time. We estimated the 2009 pandemic CFR(AR) to be 0.025%, 16-fold lower than CFR(MA). CONCLUSIONS: Data from a clinical research network yielded accurate pandemic severity estimates, including increased severity among younger people. Going forward, clinical research networks with a global presence and standardized protocols would substantially aid rapid assessment of clinical severity. CLINICAL TRIALS REGISTRATION: NCT01056354 and NCT010561.
has issue date	2018-05-08(xsd:dateTime)
bibo:doi	10.1093/cid/ciy088
bibo:pmid	29746631
has license	hybrid-oa
sha1sum (hex)	b8e388c86cc38f9a6d2adf608f93176777beab8c
schema:url	https://doi.org/10.1093/cid/ciy088
resource representing a document's title	Using Clinical Research Networks to Assess Severity of an Emerging Influenza Pandemic
has PubMed Central identifier	PMC6248856
has PubMed identifier	29746631
schema:publication	Clinical Infectious Diseases
resource representing a document's body	covid:b8e388c86cc38f9a6d2adf608f93176777beab8c#body_text
is schema:about of	named entity 'Network' named entity 'HIV' named entity 'biomarkers' named entity 'influenza' named entity 'laboratory processing' named entity 'CFR' named entity 'influenza' named entity 'cohort studies' named entity 'Taylor series' named entity 'confounder' named entity 'confidence intervals' named entity 'National Institutes of Health' named entity 'seasonal influenza' named entity 'risk factors' named entity 'probability' named entity 'CFR' named entity 'CFR' named entity 'United States' named entity 'risk factors' named entity 'influenza' named entity 'United States' named entity 'seasonal influenza' named entity 'chronic illness' named entity 'CFR' named entity 'attack rate' named entity 'CFR' named entity 'Mexico' named entity 'influenza-like illness' named entity 'WHO' named entity 'United Kingdom' named entity 'virus' named entity 'Middle East respiratory syndrome' named entity 'influenza' named entity 'epidemiological' named entity 'clinical research' named entity 'CFR' named entity 'institutional review boards' named entity 'ICMJE' named entity 'serology' named entity 'metaanalysis' named entity '2009 pandemic' named entity 'Mexico' named entity 'United States' named entity 'probability' named entity 'probability' named entity 'H3N2' named entity 'CFR' named entity 'CFR' named entity 'pH1N1' named entity 'Europe' named entity '2009 pandemic' named entity 'influenza' named entity 'CFR' named entity '1957 pandemic' named entity 'conditional probability' named entity 'outpatient' named entity '1, 2' named entity 'influenza' named entity 'delta method' named entity 'WHO' named entity 'ICU' named entity '2009 pandemic' named entity '1918 influenza pandemic' named entity 'clinical research' named entity 'influenza' named entity 'first-line'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software