About: Protection from SARS coronavirus conferred by live measles vaccine expressing the spike glycoprotein

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Protection from SARS coronavirus conferred by live measles vaccine expressing the spike glycoprotein
Creator	Tangy, Frédéric Combredet, Chantal Callendret, Benoît Escriou, Nicolas Lorin, Valérie Marianneau, Philippe Février, Michèle
Source	Elsevier; Medline; PMC
abstract	The recent identification of a novel human coronavirus responsible of a SARS-like illness in the Middle-East a decade after the SARS pandemic, demonstrates that reemergence of a SARS-like coronavirus from an animal reservoir remains a credible threat. Because SARS is contracted by aerosolized contamination of the respiratory tract, a vaccine inducing mucosal long-term protection would be an asset to control new epidemics. To this aim, we generated live attenuated recombinant measles vaccine (MV) candidates expressing either the membrane-anchored SARS-CoV spike (S) protein or its secreted soluble ectodomain (Ssol). In mice susceptible to measles virus, recombinant MV expressing the anchored full-length S induced the highest titers of neutralizing antibodies and fully protected immunized animals from intranasal infectious challenge with SARS-CoV. As compared to immunization with adjuvanted recombinant Ssol protein, recombinant MV induced stronger and Th1-biased responses, a hallmark of live attenuated viruses and a highly desirable feature for an antiviral vaccine.
has issue date	2014-01-28(xsd:dateTime)
bibo:doi	10.1016/j.virol.2014.01.002
bibo:pmid	24606680
has license	no-cc
sha1sum (hex)	b8e18afdd99dbb8dc855b5a0e188a0e869f4600f
schema:url	https://doi.org/10.1016/j.virol.2014.01.002
resource representing a document's title	Protection from SARS coronavirus conferred by live measles vaccine expressing the spike glycoprotein
has PubMed Central identifier	PMC7111909
has PubMed identifier	24606680
schema:publication	Virology
resource representing a document's body	covid:b8e18afdd99dbb8dc855b5a0e188a0e869f4600f#body_text
is schema:about of	named entity 'SARS CORONAVIRUS' named entity 'ectodomain' named entity 'recombinant' named entity 'SARS-CoV' named entity 'human' named entity 'inducing' named entity 'live attenuated' named entity 'illness' named entity 'candidates' named entity 'SARS-COV' named entity 'IMMUNIZATION' named entity 'MEASLES VACCINE' named entity 'EAST' named entity 'RECOMBINANT' named entity 'ANIMALS' named entity 'NOVEL' named entity 'VACCINE' named entity 'MIDDLE' named entity 'COMPARED' named entity 'IDENTIFICATION' named entity 'PROTECTION' named entity 'DECADE' named entity 'ANTIVIRAL' named entity 'MUCOSAL' named entity 'VIRUSES' named entity 'ATTENUATED' named entity 'SARS-LIKE CORONAVIRUS' named entity 'NEW' named entity 'LIVE MEASLES VACCINE' named entity 'PROTECTION' named entity 'ASSET' named entity 'ADJUVANTED' named entity 'RESPIRATORY TRACT' named entity 'LIVE' named entity 'MEMBRANE' named entity 'TH1' named entity 'HUMAN CORONAVIRUS' named entity 'LONG-TERM' named entity 'SOLUBLE' named entity 'NEUTRALIZING ANTIBODIES' named entity 'ILLNESS' named entity 'ITS' named entity 'GENERATED' named entity 'ANIMAL' named entity 'PROTEIN ' named entity 'RESPONSIBLE' named entity 'MICE' named entity 'INDUCED' named entity 'LENGTH' named entity 'AIM' named entity 'SECRETED' named entity 'CONTRACTED' named entity 'RESPONSES' named entity 'SUSCEPTIBLE' named entity 'SARS' named entity 'HIGHEST' named entity 'BIASED' named entity 'EPIDEMICS' named entity 'PROTEIN' named entity 'RECENT' named entity 'SPIKE' named entity 'INDUCING' named entity 'PANDEMIC' named entity 'ECTODOMAIN' named entity 'CHALLENGE' named entity 'IMMUNIZED' named entity 'CONTAMINATION' named entity 'FEATURE' named entity 'INTRANASAL' named entity 'MEASLES VIRUS' named entity 'EITHER' named entity 'FULLY' named entity 'HIGHLY' named entity '28S' named entity 'TO CONTROL'

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