About: Effect of cinnamon water extract on monocyte-to-macrophage differentiation and scavenger receptor activity

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About: Effect of cinnamon water extract on monocyte-to-macrophage differentiation and scavenger receptor activity Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Effect of cinnamon water extract on monocyte-to-macrophage differentiation and scavenger receptor activity
Creator	Kim, Young-Eun Kang, Hee Kim, Dae-Ok Nam, Tae-Gyu Park, Sung-Hyun Yun, Jeong-Moon Kim, Youn
Source	Medline; PMC
abstract	BACKGROUND: Water soluble cinnamon extract has been shown to increase insulin sensitivity and modulate macrophage activation, a desirable trait for the management of obesity or atherosclerosis. Our present study investigated whether cinnamon water extract (CWE) may influence the differentiation of monocytes into macrophages and the activity of macrophage scavenger receptors, commonly observed in atherosclerotic lesions. METHODS: We investigated the effect of CWE on the expression of various surface markers and the uptake of acetylated low density lipoprotein (LDL) in phorbol-12-myristate-13-acetate (PMA)-stimulated THP-1 cells. The protein levels of PMA or macrophage-colony stimulating factor (M-CSF)-stimulated type 1 macrophage scavenger receptor (SRA) were analyzed. Finally, the role of extracellar signal-related kinase (ERK) 1/2 in SRA synthesis and the effect of CWE on PMA-stimulated ERK1/2 were determined. RESULTS: CWE inhibited the differentiation of monocyte by decreasing the expression of CD11b, CD36 and SRA and the uptake of acetyl LDL. CWE suppressed the upregulation of SRA by M-CSF and modulated ERK1/2 activity, which was required for PMA-induced SRA synthesis. CONCLUSIONS: Our results demonstrate that CWE was able to interfere with monocyte differentiation and macrophage scavenger activity, indicating its potential in preventing the development of atherosclerotic lesions.
has issue date	2014-03-07(xsd:dateTime)
bibo:doi	10.1186/1472-6882-14-90
bibo:pmid	24602512
has license	cc-by
sha1sum (hex)	b8660d5f12c9a6a85b73207bc61291535c2700ce
schema:url	https://doi.org/10.1186/1472-6882-14-90
resource representing a document's title	Effect of cinnamon water extract on monocyte-to-macrophage differentiation and scavenger receptor activity
has PubMed Central identifier	PMC3973967
has PubMed identifier	24602512
schema:publication	BMC Complement Altern Med
resource representing a document's body	covid:b8660d5f12c9a6a85b73207bc61291535c2700ce#body_text
is schema:about of	named entity 'investigated' named entity 'differentiation' named entity 'SCAVENGER RECEPTOR ACTIVITY' named entity 'MACROPHAGE DIFFERENTIATION' named entity 'OBSERVED' named entity 'CINNAMON' named entity 'DIFFERENTIATION' named entity 'MONOCYTE' named entity 'EXTRACT' named entity 'INSULIN SENSITIVITY' named entity 'TO INCREASE' named entity 'MACROPHAGE ACTIVATION' named entity 'ACTIVITY' named entity 'PRESENT' named entity 'EXTRACT' named entity 'OBESITY' named entity 'TRAIT' named entity 'INVESTIGATED' named entity 'WATER' named entity 'OUR' named entity 'MODULATE' named entity 'MACROPHAGES' named entity 'MONOCYTES' named entity 'ATHEROSCLEROSIS' named entity 'STUDY' named entity 'INFLUENCE' named entity 'MACROPHAGE' named entity 'CINNAMON WATER' named entity 'CINNAMON WATER' named entity 'EFFECT' named entity 'SCAVENGER RECEPTORS' named entity 'BACKGROUND' named entity 'SOLUBLE' named entity 'MANAGEMENT' covid:arg/b8660d5f12c9a6a85b73207bc61291535c2700ce named entity 'sensitivity' named entity 'lesions' named entity 'desirable' named entity 'soluble' named entity 'macrophages' named entity 'atherosclerosis' named entity 'atherosclerotic' named entity 'insulin sensitivity' named entity 'macrophage' named entity 'cinnamon' named entity 'water extract' named entity 'Laboratory Animals' named entity 'noncovalently' named entity 'THP-1' named entity 'ERK1/2' named entity 'hydrophilic' named entity 'Mice' named entity 'Roche Diagnostics' named entity 'epicatechin' named entity 'integrin' named entity 'coniferyl aldehyde' named entity 'endothelial cells' named entity 'CD11b' named entity 'atherosclerosis' named entity 'LDL' named entity 'atherosclerotic lesion' named entity 'reversed-phase HPLC' named entity 'multiple comparison' named entity 'monocytes' named entity 'expression levels' named entity 'solvent' named entity 'United States National Research Council' named entity 'upregulate' named entity 'aldehyde' named entity 'THP-1' named entity 'lipids' named entity 'cinnamon' named entity 'monocytes' named entity 'enhanced chemiluminescence' named entity 'catechin'

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