About: Sulfated polymannuroguluronate TGC161 ameliorates leukopenia by inhibiting CD4(+) T cell apoptosis

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About: Sulfated polymannuroguluronate TGC161 ameliorates leukopenia by inhibiting CD4(+) T cell apoptosis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Sulfated polymannuroguluronate TGC161 ameliorates leukopenia by inhibiting CD4(+) T cell apoptosis
Creator	Li, Xu Du, Kaixin Wang, Xin Li, Li Wang, Shixin Li, Du Xu, Ximing Zang, Ruochen Han, Wenwei Yang, Jinbo Guan, Huashi Li, Chunxia Qiu, Peiju Shi, Chuanqin Xiao, Shuai Zhang, Meifang
Source	Elsevier; Medline; PMC
abstract	Polysaccharides have aroused considerable interest due to their diverse biological activities and low toxicity. In this study, we evaluated the effect of marine polysaccharide sulfated polymannuroguluronate (TGC161) on the leukopenia induced by chemotherapy. It is found that TGC161 ameliorates the leukopenia. Besides, TGC161 would promote CD4(+) T cell differentiation and maturation in the thymus, but does not have a significant effect on precursor cells in bone marrow. Furthermore, TGC161 inhibits CD4(+) T cell apoptosis in vitro. Collectively, our findings offer a natural and harmless polysaccharide to ameliorate leukopenia.
has issue date	2020-07-06(xsd:dateTime)
bibo:doi	10.1016/j.carbpol.2020.116728
bibo:pmid	32829850
has license	no-cc
sha1sum (hex)	b8625f7ef9818503cf1ff8378b3b9f514c853a8b
schema:url	https://doi.org/10.1016/j.carbpol.2020.116728
resource representing a document's title	Sulfated polymannuroguluronate TGC161 ameliorates leukopenia by inhibiting CD4(+) T cell apoptosis
has PubMed Central identifier	PMC7336955
has PubMed identifier	32829850
schema:publication	Carbohydr Polym
resource representing a document's body	covid:b8625f7ef9818503cf1ff8378b3b9f514c853a8b#body_text
is schema:about of	named entity 'NMR' named entity 'FT-IR' named entity 'chemotherapy' named entity 'antibodies' named entity 'sulfated' named entity 'CD4' named entity 'chlorosulfonic acid' named entity 'polysaccharide' named entity 'molecular weight' named entity 'lymphocytes' named entity 'antigen' named entity 'thymus' named entity 'thymus' named entity 'precursor cells' named entity 'caspase 8' named entity 'pyrazolone' named entity 'HSCs' named entity 'RPMI 1640' named entity 'CD4 +' named entity 'resazurin' named entity 'sulfate' named entity 'leukopenia' named entity 'China' named entity 'chemotherapies' named entity 'interleukin-12' named entity 'hydrolyzed' named entity 'lymphocyte' named entity 'antibodies' named entity 'Rehmannia' named entity 'leukopenia' named entity 'pyroptosis' named entity 'statistically significant' named entity 'precursor cells' named entity 'mice' named entity 'white blood cells' named entity 'mol/L' named entity 'cytokines' named entity 'peripheral blood' named entity 'Hematology Analyzer' named entity 'RNA' named entity 'brown algae' named entity 'SDS-PAGE' named entity 'leukopenia' named entity 'Darmstadt' named entity 'cell death' named entity 'weight-average molecular weight' named entity 'antibody' named entity 'centrifuged' named entity 'Multipotent' named entity 'cell culture medium' named entity 'mol/L' named entity 'Granulocyte colony stimulating factor' named entity 'CD3' named entity 'leukopenia' named entity 'KBr' named entity 'CD4 +' named entity 'FACS' named entity 'calibration curve' named entity 'macrophage phagocytosis' named entity 'colony stimulating factors' named entity 'CFSE' named entity 'penicillin' named entity 'Franklin Lake' named entity 'autoimmune' named entity 'CD8' named entity 'milk'

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