About: Antiparasitic DNA vaccines in 21(st) century

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Antiparasitic DNA vaccines in 21(st) century
Creator	Wedrychowicz, Halina
Source	PMC
abstract	Demands for effective vaccines to control parasitic diseases of humans and livestock have been recently exacerbated by the development of resistance of most pathogenic parasites to anti-parasitic drugs. Novel genomic and proteomic technologies have provided opportunities for the discovery and improvement of DNA vaccines which are relatively easy as well as cheap to fabricate and stable at room temperatures. However, their main limitation is rather poor immunogenicity, which makes it necessary to couple the antigens with adjuvant molecules. This paper review recent advances in the development of DNA vaccines to some pathogenic protozoa and helminths. Numerous studies were conducted over the past 14 years of 21(st) century, employing various administration techniques, adjuvants and new immunogenic antigens to increase efficacy of DNA vaccines. Unfortunately, the results have not been rewarding. Further research is necessary using more extensive combinations of antigens; alternate delivery systems and more efficient adjuvants based on knowledge of the immunomodulatory capacities of parasitic protozoa and helminths.
has issue date	2015-04-01(xsd:dateTime)
bibo:doi	10.1515/ap-2015-0026
bibo:pmid	26203983
has license	no-cc
sha1sum (hex)	b7e1256e7e210aa650837d8426fcfb9c1855f8cf
schema:url	https://doi.org/10.1515/ap-2015-0026
resource representing a document's title	Antiparasitic DNA vaccines in 21(st) century
has PubMed Central identifier	PMC7088677
has PubMed identifier	26203983
schema:publication	Acta Parasitol
resource representing a document's body	covid:b7e1256e7e210aa650837d8426fcfb9c1855f8cf#body_text
is schema:about of	named entity 'couple' named entity 'protozoa' named entity 'temperatures' named entity 'proteomic' named entity 'Novel' named entity 'Antiparasitic' named entity 'EXACERBATED BY' named entity 'COMBINATIONS' named entity 'DISCOVERY' named entity 'DRUGS' named entity 'RESEARCH' named entity 'CENTURY' named entity 'ADJUVANT' named entity 'RESULTS' named entity 'STABLE' named entity 'IMMUNOGENICITY' named entity 'RECENT' named entity 'PAPER' named entity 'studies' named entity 'antigens' named entity 'paper' named entity 'immunogenicity' named entity 'genomic' named entity 'DNA vaccines' named entity 'antigens' named entity 'DNA vaccines' named entity 'proteomic' named entity 'delivery systems' named entity 'adjuvants' named entity 'Antiparasitic' named entity 'parasitic diseases' named entity 'effective' named entity 'livestock' named entity 'viral vector' named entity 'MVA' named entity 'parasitic infections' named entity 'cellular machinery' named entity 'gut microbiota' named entity 'regulatory T cells' named entity 'ruminant' named entity 'MHC' named entity 'hormonal cycle' named entity 'plasmids' named entity 'vaccination' named entity 'molar' named entity 'gene' named entity 'bacteria' named entity 'eosinophils' named entity 'Th2 response' named entity 'enhancers' named entity 'antigen' named entity 'Vaccination' named entity 'cytokine' named entity 'TH2' named entity 'phospholipid bilayers' named entity 'liposomes' named entity 'Kofta' named entity 'F. hepatica' named entity 'DNA vaccines' named entity 'B-cells' named entity 'DNA vaccination' named entity 'malaria transmission' named entity 'intramuscular' named entity 'antibody' named entity 'intracellular' named entity 'mice' named entity 'malaria' named entity 'adjuvants' named entity 'plasmid DNA' named entity 'large mammals' named entity 'immune response' named entity 'laboratory animal' named entity 'plasmids' named entity 'MHC' named entity 'prime-boost' named entity 'specific immune response' named entity 'bacteria' named entity 'bacterial DNA' named entity 'protein expression' named entity 'physicochemical' named entity 'experimental studies'

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