About: Spatiotemporal DNA methylome dynamics of the developing mouse fetus

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Spatiotemporal DNA methylome dynamics of the developing mouse fetus
Creator	Li, Bin Huang, Hui Williams, Brian Ecker, Joseph Amrhein, Henry Castanon, Rosa Chen, Huaming Dickel, Diane Fang, Rongxin Gorkin, David Hariharan, Manoj He, Yupeng Lee, Ah Luo, Chongyuan Nery, Joseph Pennacchio, Len Ren, Bing Trout, Diane Visel, Axel Zhao, Yuan
Source	PMC
abstract	Cytosine DNA methylation is essential for mammalian development but understanding of its spatiotemporal distribution in the developing embryo remains limited(1,2). Here, as part of the mouse Encyclopedia of DNA Elements (ENCODE) project, we profiled 168 methylomes from 12 mouse tissues or organs at 9 developmental stages from embryogenesis to adulthood. We identified 1,808,810 genomic regions that showed variations in CG methylation by comparing the methylomes of different tissues or organs from different developmental stages. These DNA elements predominantly lose CG methylation during fetal development, whereas the trend is reversed after birth. During late stages of fetal development, non-CG methylation accumulated within the bodies of key developmental transcription factor genes, coinciding with their transcriptional repression. Integration of genome-wide DNA methylation, histone modification and chromatin accessibility data enabled us to predict 461,141 putative developmental tissue-specific enhancers, the human orthologues of which were enriched for disease-associated genetic variants. These spatiotemporal epigenome maps provide a resource for studies of gene regulation during tissue or organ progression, and a starting point for investigating regulatory elements that are involved in human developmental disorders.
has issue date	2020-07-29(xsd:dateTime)
bibo:doi	10.1038/s41586-020-2119-x
bibo:pmid	32728242
has license	cc-by
sha1sum (hex)	b75db0e01f40a3bb91aa022a23c1f4d648e47a66
schema:url	https://doi.org/10.1038/s41586-020-2119-x
resource representing a document's title	Spatiotemporal DNA methylome dynamics of the developing mouse fetus
has PubMed Central identifier	PMC7398276
has PubMed identifier	32728242
schema:publication	Nature
resource representing a document's body	covid:b75db0e01f40a3bb91aa022a23c1f4d648e47a66#body_text
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