About: High Resolution Analysis of Respiratory Syncytial Virus Infection In Vivo

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	High Resolution Analysis of Respiratory Syncytial Virus Infection In Vivo
Creator	Aljabr, Waleed Armstrong, Stuart Cloutman-Green, Elaine Pollakis, Georgios Touzelet, Olivier Hiscox, Julian Matthews, David Rickett, Natasha
Source	Medline; PMC
abstract	Human respiratory syncytial virus (HRSV) is a major cause of pediatric infection and also causes disease in the elderly and those with underlying respiratory problems. There is no vaccine for HRSV and anti-viral therapeutics are not broadly applicable. To investigate the effect of HRSV biology in children, nasopharyngeal aspirates were taken from children with different viral loads and a combined high throughput RNAseq and label free quantitative proteomics approach was used to characterize the nucleic acid and proteins in these samples. HRSV proteins were identified in the nasopharyngeal aspirates from infected children, and their abundance correlated with viral load (Ct value), confirming HRSV infection. Analysis of the HRSV genome indicated that the children were infected with sub-group A virus and that minor variants in nucleotide frequency occurred in discrete clusters along the HRSV genome, and within a patient clustered distinctly within the glycoprotein gene. Data from the samples were binned into four groups; no-HRSV infection (control), high viral load (Ct < 20), medium viral load (Ct = 20–25), and low viral load (Ct > 25). Cellular proteins associated with the anti-viral response (e.g., ISG15) were identified in the nasopharyngeal aspirates and their abundance was correlated with viral load. These combined approaches have not been used before to study HRSV biology in vivo and can be readily applied to the study the variation of virus host interactions.
has issue date	2019-10-10(xsd:dateTime)
bibo:doi	10.3390/v11100926
bibo:pmid	31658630
has license	cc-by
sha1sum (hex)	b73ed47108764542fff45d065e68ec160f10432a
schema:url	https://doi.org/10.3390/v11100926
resource representing a document's title	High Resolution Analysis of Respiratory Syncytial Virus Infection In Vivo
has PubMed Central identifier	PMC6832471
has PubMed identifier	31658630
schema:publication	Viruses
resource representing a document's body	covid:b73ed47108764542fff45d065e68ec160f10432a#body_text
is schema:about of	named entity 'infection' named entity 'biology' named entity 'W.A.' named entity 'W.A.' named entity 'study' named entity 'clusters' named entity 'broadly' named entity 'W.A.' named entity 'therapeutics' named entity 'virus' named entity '20%' named entity 'VIRUS' named entity 'INDICATED' named entity '20-25' named entity 'ELDERLY' named entity 'CORRELATED' named entity 'ANOVA' named entity 'APPROACHES' named entity 'PROJECT' named entity 'COMBINED' named entity 'SUB-' named entity 'DATA CURATION' named entity 'IDENTIFIED' named entity 'VALUE' named entity 'GROUP A' named entity 'HIGH' named entity 'LABEL FREE' named entity 'LOW' named entity 'BIOLOGY' named entity 'EFFECT' named entity 'ANTI-VIRAL RESPONSE' named entity 'VACCINE' named entity 'A.M.' named entity 'CLUSTERED' named entity 'USED' named entity 'HIGH THROUGHPUT' named entity 'NASOPHARYNGEAL' named entity 'APPLICABLE' named entity 'PROTEINS' named entity 'GROUPS' named entity 'NUCLEOTIDE' named entity 'THERAPEUTICS' named entity 'ACQUISITION' named entity 'ASPIRATES' named entity 'METHODOLOGY' named entity 'TABLE' named entity 'PREPARATION' named entity 'CHILDREN' named entity 'VIRUS HOST' named entity 'THESE' named entity 'SUPERVISION' named entity 'RESPIRATORY PROBLEMS' named entity 'PATIENT' named entity 'RNASEQ' named entity 'ABUNDANCE' named entity 'TAKEN' named entity 'REVIEW' named entity 'ADMINISTRATION' named entity 'CONFIRMING' named entity 'DRAFT' named entity 'DATA' named entity 'ISG15' named entity 'FUNDING' named entity 'THEIR' named entity 'FREQUENCY' named entity 'WRITING' named entity 'CELLULAR' named entity 'HUMAN RESPIRATORY SYNCYTIAL VIRUS' named entity 'TO CHARACTERIZE' named entity 'CLUSTERS' named entity 'VARIANTS' named entity 'GENOME' named entity 'H.%' named entity 'IS A'

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