About: Elucidating the Interaction of CF Airway Epithelial Cells and Rhinovirus: Using the Host-Pathogen Relationship to Identify Future Therapeutic Strategies

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About: Elucidating the Interaction of CF Airway Epithelial Cells and Rhinovirus: Using the Host-Pathogen Relationship to Identify Future Therapeutic Strategies Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Elucidating the Interaction of CF Airway Epithelial Cells and Rhinovirus: Using the Host-Pathogen Relationship to Identify Future Therapeutic Strategies
Creator	Pickles, Raymond Kicic, Anthony Lassmann, Timo Ling, Kak-Ming Stick, Stephen Ausrec, Becq, Frederic Garratt, Luke Moss, Richard
source	Medline; PMC
abstract	Chronic lung disease remains the primary cause of mortality in cystic fibrosis (CF). Growing evidence suggests respiratory viral infections are often more severe in CF compared to healthy peers and contributes to pulmonary exacerbations (PEx) and deterioration of lung function. Rhinovirus is the most prevalent respiratory virus detected, particularly during exacerbations in children with CF <5 years old. However, even though rhinoviral infections are likely to be one of the factors initiating the onset of CF lung disease, there is no effective targeted treatment. A better understanding of the innate immune responses by CF airway epithelial cells, the primary site of infection for viruses, is needed to identify why viral infections are more severe in CF. The aim of this review is to present the clinical impact of virus infection in both young children and adults with CF, focusing on rhinovirus infection. Previous in vitro and in vivo investigations looking at the mechanisms behind virus infection will also be summarized. The review will finish on the potential of transcriptomics to elucidate the host-pathogen responses by CF airway cells to viral infection and identify novel therapeutic targets.
has issue date	2018-11-07(xsd:dateTime)
bibo:doi	10.3389/fphar.2018.01270
bibo:pmid	30464745
has license	cc-by
sha1sum (hex)	b72fc0df422070e077cfd05d8db51dfb059b9fd7
schema:url	https://doi.org/10.3389/fphar.2018.01270
resource representing a document's title	Elucidating the Interaction of CF Airway Epithelial Cells and Rhinovirus: Using the Host-Pathogen Relationship to Identify Future Therapeutic Strategies
has PubMed Central identifier	PMC6234657
has PubMed identifier	30464745
schema:publication	Front Pharmacol
resource representing a document's body	covid:b72fc0df422070e077cfd05d8db51dfb059b9fd7#body_text
is schema:about of	named entity 'EPITHELIAL CELLS' named entity 'Future' named entity 'Interaction' named entity 'TO IDENTIFY' named entity 'THERAPEUTIC' named entity 'STRATEGIES' named entity 'RHINOVIRUS' named entity 'AIRWAY' named entity 'INTERACTION' named entity 'MINI' named entity 'REVIEW' named entity 'PATHOGEN' named entity 'RELATIONSHIP' named entity 'USING' named entity 'FUTURE' named entity 'HOST' named entity 'infection' named entity 'host-pathogen interactions' named entity 'cytotoxic effects' named entity 'neutrophil' named entity 'Relationship' named entity 'Host-Pathogen' named entity 'trachea' named entity 'FIGURE 1' named entity 'mutation' named entity 'infection' named entity 'infection' named entity 'signal transduction' named entity 'uncoating' named entity 'Type 1' named entity 'N-terminal' named entity 'inflammation' named entity 'trifluridine' named entity 'infection' named entity 'proangiogenic' named entity 'antigenic diversity' named entity 'dengue' named entity 'infection' named entity 'drug discovery' named entity 'RSV' named entity 'goblet cells' named entity 'parainfluenza' named entity 'single stranded RNA' named entity 'virus entry' named entity 'gene' named entity 'single cell' named entity 'genomes' named entity 'NK cells' named entity 'epithelial cells' named entity 'neutrophilic' named entity 'submucosal glands' named entity 'capsid protein' named entity 'antiviral' named entity 'GM-CSF' named entity 'transcriptomics' named entity 'epithelial cells' named entity 'sustained release' named entity 'proinflammatory' named entity 'viral replication' named entity 'inflammation' named entity 'goblet cells' named entity 'high-throughput' named entity 'antigen' named entity 'ZO-1' named entity 'primary bronchi' named entity 'pseudostratified epithelium' named entity 'genetic disease' named entity 'asthma' named entity 'intravenous' named entity 'omics' named entity 'Frontiers in Pharmacology' named entity 'IL-8' named entity 'infection'

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