About: Simultaneously inhibition of HIV and HBV replication through a dual small interfering RNA expression system

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Simultaneously inhibition of HIV and HBV replication through a dual small interfering RNA expression system
Creator	Zhang, Xue Zhu, Ying Wu, Jianguo Lu, Lu Li, Yan Liu, Fang Wu, Kailang Mu, Yongxin Yang, Yongbo Hu, Jing Song, Degui
Source	Elsevier; Medline; PMC
abstract	Abstract Human immunodeficiency virus (HIV) is often acquired in individuals already infected with hepatitis B virus (HBV) as a result of shared routes of transmission. Since current options for the treatment of HIV and HBV infections are limited, there is an essential need for the development of effective therapies against HIV/HBV co-infections. RNA interference (RNAi) has been used as a powerful tool to silence genes in cells and animals. In this study, we developed a small interfering RNA generation system that expressed two different siRNAs to target the HBs gene of HBV and the gp120 gene of HIV in Bel-7402 and HEK293T cells, respectively. Our results demonstrated that the two siRNA molecules could simultaneously inhibit the expression of HBs and gp120 by 81% and 89%, respectively. In addition, dual siRNA molecules significantly decreased the production of HBs, and simultaneously inhibited the replication of HBV and HIV. This dual siRNA generation system not only proved to be a novel approach for studying functions of multiple genes simultaneously, but also provides a potential approach for the treatment and prevention of HIV and HBV co-infection.
has issue date	2007-05-31(xsd:dateTime)
bibo:doi	10.1016/j.antiviral.2006.11.004
bibo:pmid	17173982
has license	els-covid
sha1sum (hex)	b6fb677a29575435c4235e3fd4a5061a0a83471c
schema:url	https://doi.org/10.1016/j.antiviral.2006.11.004
resource representing a document's title	Simultaneously inhibition of HIV and HBV replication through a dual small interfering RNA expression system
has PubMed Central identifier	PMC7114121
has PubMed identifier	17173982
schema:publication	Antiviral Research
resource representing a document's body	covid:b6fb677a29575435c4235e3fd4a5061a0a83471c#body_text
is schema:about of	named entity 'acquired' named entity 'effective' named entity 'small interfering RNA' named entity 'potential' named entity 'HIV' named entity 'Since' named entity 'infections' named entity 'transmission' named entity 'HIV' named entity 'HBV' named entity 'POTENTIAL' named entity 'PREVENTION OF' named entity 'DUAL' named entity 'HBV' named entity 'OPTIONS' named entity 'HIV' named entity 'NEED FOR' named entity 'INFECTIONS' named entity 'GENE' named entity 'APPROACH' named entity 'SIRNA' named entity 'NOVEL' named entity 'ACQUIRED' named entity 'SIRNAS' named entity 'DEVELOPMENT' named entity 'DECREASED' named entity 'HBS' named entity 'FUNCTIONS' named entity 'SMALL INTERFERING RNA' named entity 'CO-INFECTION' named entity 'REPLICATION' named entity 'DIFFERENT' named entity 'SIMULTANEOUSLY' named entity 'PROVIDES' named entity 'CO-INFECTIONS' named entity 'BUT' named entity 'ESSENTIAL' named entity 'EXPRESSED' named entity 'HIV' named entity 'EXPRESSION SYSTEM' named entity 'INHIBITION' named entity 'RNA EXPRESSION' named entity 'SMALL INTERFERING RNA' named entity 'DUAL' named entity 'BEL-7402' named entity 'LIMITED' named entity 'ANIMALS' named entity 'STUDY' named entity 'TARGET' named entity 'GENES' named entity 'USED' named entity 'REPLICATION' named entity 'ADDITION' named entity 'EXPRESSION' named entity 'TOOL' named entity 'SHARED' named entity 'RNA INTERFERENCE' named entity 'PRODUCTION' named entity 'RESULTS' named entity 'AS A RESULT OF' named entity 'THERAPIES' named entity 'SIMULTANEOUSLY' named entity 'GP120' named entity 'HUMAN IMMUNODEFICIENCY VIRUS' named entity 'SILENCE' named entity 'OUR' named entity 'HEPATITIS B VIRUS' named entity 'GENERATION' named entity 'TRANSMISSION' named entity 'ROUTES' named entity 'SYSTEM'

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