About: Innate immune signaling in the olfactory epithelium reduces odorant receptor levels: modeling transient smell loss in COVID-19 patients

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About: Innate immune signaling in the olfactory epithelium reduces odorant receptor levels: modeling transient smell loss in COVID-19 patients Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Innate immune signaling in the olfactory epithelium reduces odorant receptor levels: modeling transient smell loss in COVID-19 patients
Creator	Yu, C Mukerji, Shibani Boyer, Edward Brandon Westover, M Holbrook, Eric Magdamo, Colin Zafonte, Ross Albers, Alefiya Albers, Mark Benz, Eric Cao, Luxiang Evans, Kyle Gallagher, Rose Ramirez Gomez, Liliana Rickenbacher, Gregory Rodriguez, Steven Tatar, Daniel
Source	MedRxiv; Medline; PMC
abstract	Post-infectious anosmias typically follow death of olfactory sensory neurons (OSNs) with a months-long recovery phase associated with parosmias. While profound anosmia is the leading symptom associated with COVID-19 infection, many patients regain olfactory function within days to weeks without distortions. Here, we demonstrate that sterile induction of anti-viral type I interferon signaling in the mouse olfactory epithelium is associated with diminished odor discrimination and reduced odor-evoked local field potentials. RNA levels of all class I, class II, and TAAR odorant receptors are markedly reduced in OSNs in a non-cell autonomous manner. We find that people infected with COVID-19 rate odors with lower intensities and have odor discrimination deficits relative to people that tested negative for COVID-19. Taken together, we propose that inflammatory-mediated loss of odorant receptor expression with preserved circuit integrity accounts for the profound anosmia and rapid recovery of olfactory function without parosmias caused by COVID-19.
has issue date	2020-06-16(xsd:dateTime)
bibo:doi	10.1101/2020.06.14.20131128
bibo:pmid	32587994
has license	cc-by-nc-nd
sha1sum (hex)	b6c5d81e178f0d20a35161d6845cdf44f806d7a7
schema:url	https://doi.org/10.1101/2020.06.14.20131128
resource representing a document's title	Innate immune signaling in the olfactory epithelium reduces odorant receptor levels: modeling transient smell loss in COVID-19 patients
has PubMed Central identifier	PMC7310652
has PubMed identifier	32587994
schema:publication	medRxiv
resource representing a document's body	covid:b6c5d81e178f0d20a35161d6845cdf44f806d7a7#body_text
is schema:about of	named entity 'odors' named entity 'olfactory sensory neurons' named entity 'negative' named entity 'COVID-19' named entity 'loss' named entity 'odorant receptor' named entity 'INTENSITIES' named entity 'olfactory function' named entity 'levels' named entity 'anti-viral' named entity 'anosmia' named entity 'RNA' named entity 'odor' named entity 'infection' named entity 'odorant receptors' named entity 'olfactory function' named entity 'inflammatory' named entity 'circuit integrity' named entity 'odorant receptor' named entity 'odorant receptor' named entity 'COVID-19' named entity 'Local field potentials' named entity 'odorant receptors' named entity 'EIF2A' named entity 'Nd1' named entity 'medRxiv' named entity 'odorant receptors' named entity 'signaling cascade' named entity 'filter paper' named entity 'OSN' named entity 'olfactory epithelium' named entity 'innate immune response' named entity 'ethyl acetate' named entity 'mouse models' named entity 'COVID-19' named entity 'olfactory function' named entity 'anti-viral' named entity 'protein kinase' named entity 'sustentacular cell' named entity 'SARS-CoV-2' named entity 'Sendai virus' named entity '1:2' named entity 'transgene' named entity 'transcription' named entity 'hyperactive' named entity 'Nd1' named entity 'neurotoxic' named entity 'medRxiv' named entity 'operant conditioning' named entity 'olfactory' named entity 'Nd1' named entity 'genomically' named entity 'olfactory bulb' named entity 'clinical features' named entity 'epithelia' named entity 'protein kinase' named entity 'young adult' named entity 'antiviral' named entity 'olfactory function' named entity 'odorant receptors' named entity 'anosmic' named entity 'parafilm' named entity 'electronic health record' named entity 'odorant receptors' named entity 'Anosmia'

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