About: Multi-Antigenic Virus-like Particle of SARS CoV-2 produced in Saccharomyces cerevisiae as a vaccine candidate

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About: Multi-Antigenic Virus-like Particle of SARS CoV-2 produced in Saccharomyces cerevisiae as a vaccine candidate Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Multi-Antigenic Virus-like Particle of SARS CoV-2 produced in Saccharomyces cerevisiae as a vaccine candidate
Creator	Singh, Kumar Arora, Kajal Arora, Mehrotra Arya, Vidya Bansal, Sarthi Fengade, Surendra Kalyanaraman, Sriganesh Kumar, Bibekanand Kumar, Devanand Kundu, Kumar Naqvi, Aelia Paliwal, Jeny Parashar, Deepak Potdar, Swaroop Rastogi, Ruchir Rautray, Satabdi Singh, Indrajeet Srivastava, Apoorva
source	BioRxiv
abstract	Spike, Envelope and Membrane proteins from the SARS CoV-2 virus surface coat are important vaccine targets. We hereby report recombinant co-expression of the three proteins (Spike, Envelope and Membrane) in a engineered Saccharomyces cerevisiae platform (D-Crypt™) and their self-assembly as Virus-like particle (VLP). This design as a multi-antigenic VLP for SARS CoV-2 has the potential to be a scalable vaccine candidate. The VLP is confirmed by transmission electron microscopy (TEM) images of the SARS CoV-2, along with supportive HPLC, Dynamic Light Scattering (DLS) and allied analytical data. The images clearly outline the presence of a “Corona” like morphology, and uniform size distribution.
has issue date	2020-05-19(xsd:dateTime)
bibo:doi	10.1101/2020.05.18.099234
has license	biorxiv
sha1sum (hex)	b6c43128e0b7a310f52dae34130dcfde4e243f5f
schema:url	https://doi.org/10.1101/2020.05.18.099234
resource representing a document's title	Multi-Antigenic Virus-like Particle of SARS CoV-2 produced in Saccharomyces cerevisiae as a vaccine candidate
schema:publication	bioRxiv
resource representing a document's body	covid:b6c43128e0b7a310f52dae34130dcfde4e243f5f#body_text
is schema:about of	named entity 'DATA' named entity 'SURFACE' named entity 'SELF-ASSEMBLY' named entity 'RECOMBINANT' named entity 'VLP' named entity 'PROTEINS' named entity 'TARGETS' named entity 'self-assembly' named entity 'transmission electron microscopy' named entity 'SARS CoV' named entity 'SARS CoV' named entity 'vaccine' named entity 'TEM' named entity 'VLP' named entity 'vaccine' named entity 'Antigenic' named entity 'protein' named entity 'structural proteins' named entity 'VLPs' named entity 'protein' named entity 'VLPs' named entity 'Infinity II' named entity 'cell lysate' named entity 'protein' named entity 'transmission electron microscope' named entity 'peptide mapping' named entity 'protein' named entity 'kDa' named entity 'antibody' named entity 'selective media' named entity 'protein' named entity 'vaccine' named entity 'VLP' named entity 'vaccines' named entity 'Electron microscopy' named entity 'protease' named entity 'gene' named entity 'genome' named entity 'recombinant' named entity 'Lithium acetate' named entity 'SARS-CoV-2' named entity 'protein' named entity 'SARS-CoV-2' named entity 'Western blot' named entity 'Tosoh' named entity 'vaccine' named entity 'light scattering' named entity 'SEC' named entity 'uranyl acetate' named entity 'viral capsid' named entity 'clones' named entity 'TEM' named entity 'VLP' named entity 'immunogenicity' named entity 'morphology' named entity 'Glucose' named entity 'OD600' named entity 'protein' named entity 'seed' named entity 'yeast' named entity 'scattering' named entity 'self-assembly' named entity 'Lithium acetate' named entity 'vaccine' named entity 'Glucose' named entity 'sodium phosphate' named entity 'disruption of cells'

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