About: Dendritic Cell Immunoreceptor Is a New Target for Anti-AIDS Drug Development: Identification of DCIR/HIV-1 Inhibitors

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Dendritic Cell Immunoreceptor Is a New Target for Anti-AIDS Drug Development: Identification of DCIR/HIV-1 Inhibitors
Creator	Azzi, Arezki Gilbert, Caroline Lin, Sheng-Xiang Tremblay, Michel Lambert, Alexandra St-Gelais, Karianne Ve Allaire, Geneviè
source	PMC
abstract	The HIV-1 pandemic continues to expand while no effective vaccine or cure is yet available. Existing therapies have managed to limit mortality and control viral proliferation, but are associated with side effects, do not cure the disease and are subject to development of resistance. Finding new therapeutic targets and drugs is therefore crucial. We have previously shown that the dendritic cell immunoreceptor (DCIR), a C-type lectin receptor expressed on dendritic cells (DCs), acts as an attachment factor for HIV-1 to DCs and contributes to HIV-1 transmission to CD4(+) T lymphocytes (CD4TL). Directly involved in HIV-1 infection, DCIR is expressed in apoptotic or infected CD4TL and promotes trans-infection to bystander cells. Here we report the 3D modelling of the extracellular domain of DCIR. Based on this structure, two surface accessible pockets containing the carbohydrate recognition domain and the EPS binding motif, respectively, were targeted for screening of chemicals that will disrupt normal interaction with HIV-1 particle. Preliminary screening using Raji-CD4-DCIR cells allowed identification of two inhibitors that decreased HIV-1 attachment and propagation. The impact of these inhibitors on infection of DCs and CD4TL was evaluated as well. The results of this study thus identify novel molecules capable of blocking HIV-1 transmission by DCs and CD4TL.
has issue date	2013-07-09(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0067873
bibo:pmid	23874461
has license	cc-by
sha1sum (hex)	b6682adfe5026c78e3d59b165126abfa8945eb5f
schema:url	https://doi.org/10.1371/journal.pone.0067873
resource representing a document's title	Dendritic Cell Immunoreceptor Is a New Target for Anti-AIDS Drug Development: Identification of DCIR/HIV-1 Inhibitors
has PubMed Central identifier	PMC3706466
has PubMed identifier	23874461
schema:publication	PLoS One
resource representing a document's body	covid:b6682adfe5026c78e3d59b165126abfa8945eb5f#body_text
is schema:about of	named entity 'T lymphocytes' named entity 'pockets' named entity 'viral' named entity 'Finding' named entity 'normal' named entity 'accessible' named entity 'Development' named entity 'AIDS DRUG' named entity 'IDENTIFICATION' named entity 'HIV-1' named entity 'IMPACT' named entity 'APOPTOTIC' named entity 'HIV-1 INFECTION' named entity 'ALLOWED' named entity 'TRANS' named entity 'DO NOT' named entity 'DENDRITIC CELL IMMUNORECEPTOR' named entity 'CONTROL' named entity 'CARBOHYDRATE' named entity 'BUT' named entity 'BINDING' named entity 'ATTACHMENT' named entity 'PARTICLE' named entity 'PROPAGATION' named entity 'DEVELOPMENT' named entity 'IDENTIFY' named entity 'EXTRACELLULAR DOMAIN' named entity 'DCS' named entity 'SURFACE' named entity 'LIMIT' named entity 'MOLECULES' named entity 'CURE' named entity 'STUDY' named entity 'DENDRITIC CELLS' named entity 'THESE' named entity 'DECREASED' named entity 'EPS' named entity 'THERAPIES' named entity 'RECOGNITION' named entity 'RESULTS' named entity 'SCREENING' named entity 'INTERACTION' named entity 'CHEMICALS' named entity 'CAPABLE' named entity 'TARGETED' named entity 'T LYMPHOCYTES' named entity 'RESISTANCE' named entity 'DISEASE' named entity 'USING' named entity 'HERE' named entity 'DCIR' named entity 'HAVE' named entity 'ACTS' named entity 'BASED' named entity 'CELLS' named entity 'IDENTIFICATION' named entity 'INFECTED' named entity 'DOMAIN' named entity 'BLOCKING' named entity 'FACTOR' named entity 'DCIR' named entity 'EXPAND' named entity 'ACCESSIBLE' named entity 'TRANSMISSION' named entity 'PANDEMIC' named entity 'VACCINE' named entity 'DENDRITIC CELL IMMUNORECEPTOR' named entity 'INHIBITORS' named entity 'NEW TARGET' named entity 'DRUG DEVELOPMENT' named entity 'PREVIOUSLY' named entity 'DISRUPT' named entity 'BYSTANDER' named entity 'PRELIMINARY' named entity 'AVAILABLE'

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