About: Correlation between TGF‐β1 expression and proteomic profiling induced by severe acute respiratory syndrome coronavirus papain‐like protease

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About: Correlation between TGF‐β1 expression and proteomic profiling induced by severe acute respiratory syndrome coronavirus papain‐like protease Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Correlation between TGF‐β1 expression and proteomic profiling induced by severe acute respiratory syndrome coronavirus papain‐like protease
Creator	Lin, Cheng-Wen Lin, Ying-Ju Wan, Lei Li, Shih-Wen Yang, Tsuey-Ching Lai, Chien-Chen Tsai, Fuu-Jen
Source	Medline; PMC
abstract	Severe acute respiratory syndrome (SARS) coronavirus (SARS‐CoV) papain‐like protease (PLpro), a deubiquitinating enzyme, demonstrates inactivation of interferon (IFN) regulatory factor 3 and NF‐κB, reduction of IFN induction, and suppression of type I IFN signaling pathway. This study investigates cytokine expression and proteomic change induced by SARS‐CoV PLpro in human promonocyte cells. PLpro significantly increased TGF‐β1 mRNA expression (greater than fourfold) and protein production (greater than threefold). Proteomic analysis, Western blot, and quantitative real‐time PCR assays indicated PLpro upregulating TGF‐β1‐associated genes: HSP27, protein disulfide isomerase A3 precursor, glial fibrillary acidic protein, vimentin, retinal dehydrogenase 2, and glutathione transferase omega‐1. PLpro‐activated ubiquitin proteasome pathway via upregulation of ubiquitin‐conjugating enzyme E2–25k and proteasome subunit alpha type 5. Proteasome inhibitor MG‐132 significantly reduced expression of TGF‐β1 and vimentin. PLpro upregulated HSP27, linking with activation of p38 MAPK and ERK1/2 signaling. Treatment with SB203580 and U0126 reduced PLpro‐induced expression of TGF‐β1, vimentin, and type I collagen. Results point to SARS‐CoV PLpro triggering TGF‐β1 production via ubiquitin proteasome, p38 MAPK, and ERK1/2‐mediated signaling.
has issue date	2012-10-05(xsd:dateTime)
bibo:doi	10.1002/pmic.201200225
bibo:pmid	22936401
has license	no-cc
sha1sum (hex)	b5b80cf9452339bf06419e67855da5c9fae083de
schema:url	https://doi.org/10.1002/pmic.201200225
resource representing a document's title	Correlation between TGF‐β1 expression and proteomic profiling induced by severe acute respiratory syndrome coronavirus papain‐like protease
has PubMed Central identifier	PMC7168038
has PubMed identifier	22936401
schema:publication	Proteomics
resource representing a document's body	covid:b5b80cf9452339bf06419e67855da5c9fae083de#body_text
is schema:about of	named entity 'cells' named entity 'SARS-CoV' named entity 'HSP27' named entity 'reduced' named entity 'signaling pathway' named entity 'profiling' named entity 'PROMONOCYTE' named entity 'ACTIVATION OF P38 MAPK' named entity 'A41' named entity 'INDUCTION' named entity 'REDUCED' named entity 'INTERFERON ' named entity 'REGULATORY' named entity 'HUMAN' named entity 'cytokine' named entity 'induced' named entity 'vimentin' named entity 'coronavirus' named entity 'protease' named entity 'human' named entity 'point' named entity 'reduction' named entity 'expression' named entity 'mediated' named entity 'Severe acute respiratory syndrome (SARS)' named entity 'study' named entity 'PLpro' named entity 'mRNA expression' named entity 'PLpro' named entity 'protein disulfide isomerase' named entity 'p38 MAPK' named entity 'Severe acute respiratory syndrome' named entity 'vimentin' named entity 'p38 MAPK' named entity 'PLpro' named entity 'type I collagen' named entity 'interferon' named entity 'type I IFN' named entity 'proteomic' named entity 'quantitative real-time PCR' named entity 'glial fibrillary acidic protein' named entity 'upregulation' named entity 'PLpro' named entity 'papain' named entity 'proteasome' named entity 'retinal dehydrogenase' named entity 'PLpro' named entity 'papain' named entity 'PLpro' named entity 'ERK1/2' named entity 'proteomic' named entity 'vimentin' named entity 'protein' named entity 'PLpro' named entity 'reagent' named entity 'U0126' named entity 'capillary' named entity 'quantitative real-time PCR' named entity 'Vimentin' named entity 'mRNA' named entity 'capillary' named entity 'PLpro' named entity 'PBS' named entity 'cytoskeleton' named entity 'vimentin' named entity 'induced expression' named entity 'PLpro' named entity 'proteasome inhibitor' named entity 'ubiquitin' named entity 'Bio-Rad' named entity 'lung fibrosis' named entity 'protein disulfide isomerase' named entity 'SARS-CoV' named entity 'PLpro' named entity 'PANTHER'

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