About: Accuracy of comprehensive PCR analysis of nasopharyngeal and oropharyngeal swabs for CT-scan-confirmed pneumonia in elderly patients: a prospective cohort study

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About: Accuracy of comprehensive PCR analysis of nasopharyngeal and oropharyngeal swabs for CT-scan-confirmed pneumonia in elderly patients: a prospective cohort study Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Accuracy of comprehensive PCR analysis of nasopharyngeal and oropharyngeal swabs for CT-scan-confirmed pneumonia in elderly patients: a prospective cohort study
Creator	Kaiser, L Janssens, J Mamin, A Fubini, P Garin, N Huttner, B Marti, C Meynet, M Montet, X Prendki, V Reny, J Scheffler, M Stirnemann, J
Source	Elsevier; Medline; PMC
abstract	OBJECTIVES: We aimed to assess the accuracy of PCR detection of viruses and bacteria on nasopharyngeal and oropharyngeal swabs (NPS) for the diagnosis of pneumonia in elderly individuals. METHODS: We included consecutive hospitalized elderly individuals suspected of having pneumonia. At inclusion, NPS were collected from all participants and tested by PCR for the presence of viral and bacterial respiratory pathogens (index test, defined as comprehensive molecular testing). Routine diagnostic tests (blood and sputum culture, urine antigen detection) were also performed. The reference standard was the presence of pneumonia on a low-dose CT scan as assessed by two independent expert radiologists. RESULTS: The diagnosis of pneumonia was confirmed in 127 of 199 (64%) included patients (mean age 83 years, community-acquired pneumonia in 105 (83%)). A pathogen was identified by comprehensive molecular testing in 114 patients (57%) and by routine methods in 22 (11%). Comprehensive molecular testing was positive for viruses in 62 patients (31%) and for bacteria in 73 (37%). The sensitivity and specificity were 61% (95% CI 53%–69%) and 50% (95% CI 39%–61%) for comprehensive molecular testing, and 14% (95% CI 82%–21%) and 94% (95% CI 86%–98%) for routine testing, respectively. Positive likelihood ratio was 2.55 for routine methods and 1.23 for comprehensive molecular testing. CONCLUSION: Comprehensive molecular testing of NPS increases the number of pathogens detected compared with routine methods, but results are poorly predictive of the presence of pneumonia. Hence, comprehensive molecular testing is unlikely to impact clinical decision-making (NCT02467192). CLINICAL TRIALS REGISTRATION: NCT02467192.
has issue date	2019-01-12(xsd:dateTime)
bibo:doi	10.1016/j.cmi.2018.12.037
bibo:pmid	30641227
has license	no-cc
sha1sum (hex)	b5a94826e12693b5217460c7ec7426516d3a47af
schema:url	https://doi.org/10.1016/j.cmi.2018.12.037
resource representing a document's title	Accuracy of comprehensive PCR analysis of nasopharyngeal and oropharyngeal swabs for CT-scan-confirmed pneumonia in elderly patients: a prospective cohort study
has PubMed Central identifier	PMC7172172
has PubMed identifier	30641227
schema:publication	Clin Microbiol Infect
resource representing a document's body	covid:b5a94826e12693b5217460c7ec7426516d3a47af#body_text
is schema:about of	named entity 'elderly' named entity 'presence' named entity 'testing' named entity 'diagnosis' named entity 'elderly' named entity 'bacterial' named entity 'CLINICAL DECISION-MAKING' named entity 'COMMUNITY-ACQUIRED PNEUMONIA' named entity 'METHODS' named entity 'NPS' named entity 'ACCURACY' named entity 'DEFINED' named entity 'IDENTIFIED BY' named entity 'YEARS' named entity 'PATHOGEN' named entity 'ANTIGEN DETECTION' named entity 'INDEPENDENT' named entity 'PARTICIPANTS' named entity 'REFERENCE STANDARD' named entity 'NUMBER OF' named entity 'NPS' named entity 'NPS' named entity 'assessed' named entity 'confirmed' named entity 'PCR' named entity 'testing' named entity 'respiratory' named entity 'molecular' named entity 'individuals' named entity 'inclusion' named entity 'patients' named entity 'pneumonia' named entity 'diagnostic tests' named entity 'oropharyngeal' named entity 'urine' named entity 'sensitivity and specificity' named entity 'community-acquired pneumonia' named entity '95% CI' named entity 'pneumonia' named entity 'elderly individuals' named entity '95% CI' named entity 'PCR' named entity 'pathogens' named entity 'molecular testing' named entity 'bacteria' named entity 'Positive likelihood ratio' named entity 'CT scan' named entity 'pathogens' named entity 'diagnostic tests' named entity 'antigen' named entity 'nasopharyngeal' named entity 'elderly patients' named entity 'prospective cohort study' named entity 'nasopharyngeal' named entity 'sputum' named entity 'LDCT' named entity 'infection' named entity 'Moraxella catarrhalis' named entity 'molecular testing' named entity 'bacteria' named entity 'symptom' named entity 'community-acquired pneumonia' named entity 'oropharyngeal' named entity 'viruses' named entity 'Geneva' named entity 'PCR' named entity 'molecular testing' named entity 'multiplex PCR' named entity 'influenza virus'

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