About: The efficacy of medical masks and respirators against respiratory infection in healthcare workers

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The efficacy of medical masks and respirators against respiratory infection in healthcare workers
Creator	Wang, Quanyi Peng, Yang Chandini, Raina Macintyre, Abrar, \| Chughtai, Ahmad Rahman, \| Seale, \| Wang, \| Zhang, \|
Source	Medline; PMC
abstract	OBJECTIVE: We aimed to examine the efficacy of medical masks and respirators in protecting against respiratory infections using pooled data from two homogenous randomised control clinical trials (RCTs). METHODS: The data collected on 3591 subjects in two similar RCTs conducted in Beijing, China, which examined the same infection outcomes, were pooled. Four interventions were compared: (i) continuous N95 respirator use, (ii) targeted N95 respirator use, (iii) medical mask use and (iv) control arm. The outcomes were laboratory‐confirmed viral respiratory infection, influenza A or B, laboratory‐confirmed bacterial colonisation and pathogens grouped by mode of transmission. RESULTS: Rates of all outcomes were consistently lower in the continuous N95 and/or targeted N95 arms. In adjusted analysis, rates of laboratory‐confirmed bacterial colonisation (RR 0.33, 95% CI 0.21‐0.51), laboratory‐confirmed viral infections (RR 0.46, 95% CI 0.23‐0.91) and droplet‐transmitted infections (RR 0.26, 95% CI 0.16‐0.42) were significantly lower in the continuous N95 arm. Laboratory‐confirmed influenza was also lowest in the continuous N95 arm (RR 0.34, 95% CI 0.10‐1.11), but the difference was not statistically significant. Rates of laboratory‐confirmed bacterial colonisation (RR 0.54, 95% CI 0.33‐0.87) and droplet‐transmitted infections (RR 0.43, 95% CI 0.25‐0.72) were also lower in the targeted N95 arm, but not in medical mask arm. CONCLUSION: The results suggest that the classification of infections into droplet versus airborne transmission is an oversimplification. Most guidelines recommend masks for infections spread by droplets. N95 respirators, as “airborne precautions,” provide superior protection for droplet‐transmitted infections. To ensure the occupational health and safety of healthcare worker, the superiority of respirators in preventing respiratory infections should be reflected in infection control guidelines.
has issue date	2017-08-30(xsd:dateTime)
bibo:doi	10.1111/irv.12474
bibo:pmid	28799710
has license	cc-by
sha1sum (hex)	b56db50e2116c867bbc86aefcdfec72c74e971ed
schema:url	https://doi.org/10.1111/irv.12474
resource representing a document's title	The efficacy of medical masks and respirators against respiratory infection in healthcare workers
has PubMed Central identifier	PMC5705692
has PubMed identifier	28799710
schema:publication	Influenza Other Respir Viruses
resource representing a document's body	covid:b56db50e2116c867bbc86aefcdfec72c74e971ed#body_text
is schema:about of	named entity 'EFFICACY' named entity 'HEALTHCARE WORKERS' named entity 'RESPIRATORY INFECTION' named entity 'respirators' named entity 'respirators' covid:arg/b56db50e2116c867bbc86aefcdfec72c74e971ed named entity 'HOMOGENOUS' named entity 'EFFICACY' named entity 'PROTECTING' named entity 'POOLED' named entity 'RESPIRATORY INFECTIONS' named entity 'CLINICAL TRIALS' named entity 'MASKS' named entity 'RESPIRATORS' named entity 'CONTROL' named entity 'MASKS' named entity 'RESPIRATORS' named entity 'TO EXAMINE' named entity 'DATA' named entity 'USING' named entity 'MEDICAL' named entity 'MEDICAL' named entity 'respiratory infections' named entity 'clinical trials' named entity 'respiratory infection' named entity 'medical masks' named entity 'Medical masks' named entity 'Respirators' named entity 'respirator' named entity 'data set' named entity 'clinical trials' named entity 'Disease Prevention and Control' named entity 'randomised control trials' named entity 'coinfection' named entity 'mode of transmission' named entity 'influenza' named entity 'control arm' named entity 'statistically significant' named entity 'high-risk' named entity 'unimodal' named entity 'significant difference' named entity 'control arm' named entity 'RCT' named entity 'IPD' named entity 'medical masks' named entity 'influenza' named entity 'influenza' named entity 'medical masks' named entity 'N95' named entity 'pathogens' named entity 'N95' named entity 'serological' named entity 'cloth masks' named entity 'nuclei' named entity 'N95' named entity 'Beijing' named entity 'control arm' named entity 'healthcare workers' named entity 'Human Research Ethics Committee' named entity 'influenza infection' named entity 'fit-tested' named entity 'influenza' named entity 'laboratory testing' named entity 'respirator' named entity 'influenza' named entity 'IPD' named entity 'statistical power' named entity 'infection' named entity 'virus' named entity 'N95' named entity 'aerosolised' named entity 'nucleic acid testing'

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