About: Cooperativity Enables Non-neutralizing Antibodies to Neutralize Ebolavirus

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Cooperativity Enables Non-neutralizing Antibodies to Neutralize Ebolavirus
Creator	Shulenin, Sergey Vu, Hong Qiu, Xiangguo Davidson, Edgar Bryan, Christopher He, Shihua Kuehne, Ana Dye, John Brannan, Jennifer Doranz, Benjamin Herbert, Andrew Holtsberg, Frederick Howell, Katie Javad, M Turner, Hannah Ward, Andrew Mcneal, Andrew
Source	Elsevier; Medline; PMC
abstract	Drug combinations are synergistic when their combined efficacy exceeds the sum of the individual actions, but they rarely include ineffective drugs that become effective only in combination. We identified several ‘‘enabling pairs’’ of neutralizing and non-neutralizing anti-ebolavirus monoclonal antibodies, whose combination exhibited new functional profiles, including transforming a non-neutralizing antibody to a neutralizer. Sub-neutralizing concentrations of antibodies 2G4 or m8C4 enabled non-neutralizing antibody FVM09 (IC(50) >1 mM) to exhibit potent neutralization (IC(50) 1–10 nM). While FVM09 or m8C4 alone failed to protect Ebola-virus-infected mice, a combination of the two antibodies provided 100% protection. Furthermore, non-neutralizers FVM09 and FVM02 exponentially enhanced the potency of two neu-tralizing antibodies against both Ebola and Sudan viruses. We identified a hotspot for the binding of these enabling antibody pairs near the interface of the glycan cap and GP2. Enabling cooperativity may be an underappreciated phenomenon for viruses, with implications for the design and development of immunotherapeutics and vaccines.
has issue date	2017-04-11(xsd:dateTime)
bibo:doi	10.1016/j.celrep.2017.03.049
bibo:pmid	28402862
has license	cc-by-nc-nd
sha1sum (hex)	b533398000a2ca0d89d244e430d7eb5f3d82fc71
schema:url	https://doi.org/10.1016/j.celrep.2017.03.049
resource representing a document's title	Cooperativity Enables Non-neutralizing Antibodies to Neutralize Ebolavirus
has PubMed Central identifier	PMC6082427
has PubMed identifier	28402862
schema:publication	Cell Rep
resource representing a document's body	covid:b533398000a2ca0d89d244e430d7eb5f3d82fc71#body_text
is schema:about of	named entity 'NON-NEUTRALIZING ANTIBODIES' named entity 'SUDAN' named entity 'PROTECTION' named entity 'INEFFECTIVE' named entity 'PAIRS' named entity 'THEIR' named entity '3E1' named entity 'ENABLING' named entity 'THESE' named entity 'VIRUSES' named entity 'TRANSFORMING' named entity '100%' named entity 'COMBINATION' named entity 'MONOCLONAL ANTIBODIES' named entity 'ACTIONS' named entity 'COMBINED' named entity 'EBOLA' named entity 'IDENTIFIED' named entity 'EBOLAVIRUS' named entity 'BINDING' named entity 'NON-' named entity 'antibodies' named entity 'combined' named entity 'antibodies' named entity 'sum' named entity 'HHS' named entity 'INCLUDING' named entity 'PROVIDED' named entity 'PUBLIC' named entity '1-10' named entity 'RARELY' named entity 'ANTIBODY' named entity 'CONCENTRATIONS' named entity 'BUT' named entity 'SYNERGISTIC' named entity 'HOTSPOT' named entity 'DRUG COMBINATIONS' named entity 'ENABLES' named entity 'EBOLAVIRUS' named entity 'ACCESS' named entity '2G4' named entity 'SUM' named entity 'GP2' named entity 'POTENCY' named entity 'NEW' named entity 'INTERFACE' named entity 'EFFECTIVE' named entity 'NEAR' named entity 'NEU' named entity 'SUB-' named entity 'INDIVIDUAL' named entity 'FUNCTIONAL' named entity 'EFFICACY' named entity 'COOPERATIVITY' named entity 'MICE' named entity 'ANTIBODIES' named entity 'EXHIBIT' named entity 'NEUTRALIZING ANTIBODY' named entity 'CAP' named entity 'GLYCAN' named entity 'DRUGS' named entity 'COOPERATIVITY' named entity 'ENABLED' named entity 'INCLUDE' named entity 'FAILED'

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