About: The contribution of viruses and bacteria to community-acquired pneumonia in vaccinated children: a case

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About: The contribution of viruses and bacteria to community-acquired pneumonia in vaccinated children: a case–control study Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The contribution of viruses and bacteria to community-acquired pneumonia in vaccinated children: a case–control study
Creator	Jaffe, Adam Lang, Jurissa Sikazwe, Chisha West, Rachel Smith, David Borland, Meredith Bhuiyan, Kirkham, Lea-Ann Mejbah, Uddin Thornton, Ruth Christopher C Blyth, De Gier,, Camilla Martin, Rahman,, Tasmina Thomas L Snelling,
Source	Medline; PMC
abstract	INTRODUCTION: Respiratory pathogens associated with childhood pneumonia are often detected in the upper respiratory tract of healthy children, making their contribution to pneumonia difficult to determine. We aimed to determine the contribution of common pathogens to pneumonia adjusting for rates of asymptomatic detection to inform future diagnosis, treatment and preventive strategies. METHODS: A case–control study was conducted among children <18 years in Perth, Western Australia. Cases were children hospitalised with radiologically confirmed pneumonia; controls were healthy children identified from outpatient and local immunisation clinics. Nasopharyngeal swabs were collected and tested for 14 respiratory viruses and 6 bacterial species by Polymerase chain reaction (PCR). For each pathogen, adjusted odds ratio (aOR; 95% CI) was calculated using multivariate logistic regression and population-attributable fraction (95% CI) for pneumonia was estimated. RESULTS: From May 2015 to October 2017, 230 cases and 230 controls were enrolled. At least one respiratory virus was identified in 57% of cases and 29% of controls (aOR: 4.7; 95% CI: 2.8 to 7.8). At least one bacterial species was detected in 72% of cases and 80% of controls (aOR: 0.7; 95% CI: 0.4 to 1.2). Respiratory syncytial virus (RSV) detection was most strongly associated with pneumonia (aOR: 58.4; 95% CI: 15.6 to 217.5). Mycoplasma pneumoniae was the only bacteria associated with pneumonia (aOR: 14.5; 95% CI: 2.2 to 94.8). We estimated that RSV, human metapneumovirus (HMPV), influenza, adenovirus and Mycoplasma pneumoniae were responsible for 20.2% (95% CI: 14.6 to 25.5), 9.8% (5.6% to 13.7%), 6.2% (2.5% to 9.7%), 4% (1.1% to 7.1%) and 7.2% (3.5% to 10.8%) of hospitalisations for childhood pneumonia, respectively. CONCLUSIONS: Respiratory viruses, particularly RSV and HMPV, are major contributors to pneumonia in Australian children.
has issue date	2018-10-18(xsd:dateTime)
bibo:doi	10.1136/thoraxjnl-2018-212096
bibo:pmid	30337417
has license	cc-by-nc
sha1sum (hex)	b530a3db1f7e6d6f289cd4fa3df8a782dcb691ab
schema:url	https://doi.org/10.1136/thoraxjnl-2018-212096
resource representing a document's title	The contribution of viruses and bacteria to community-acquired pneumonia in vaccinated children: a case–control study
has PubMed Central identifier	PMC6467248
has PubMed identifier	30337417
schema:publication	Thorax
resource representing a document's body	covid:b530a3db1f7e6d6f289cd4fa3df8a782dcb691ab#body_text
is schema:about of	named entity 'BACTERIA ' named entity 'DIAGNOSIS' named entity 'CLINICS' named entity 'RSV' named entity 'RESULTS' named entity 'CASE-CONTROL STUDY' named entity 'IMMUNISATION' named entity '20.2' named entity 'COLLECTED' named entity 'WESTERN AUSTRALIA' named entity 'ODDS RATIO' named entity '1.2' named entity '282' named entity 'CHILDHOOD PNEUMONIA' named entity 'HOSPITALISATIONS' named entity 'CONTRIBUTION' named entity 'ADJUSTED' named entity '10.8' named entity '217' named entity 'IDENTIFIED' named entity 'INTRODUCTION' named entity 'POPULATION' named entity 'CALCULATED' named entity 'DETECTED' named entity 'CHILDREN' named entity 'OCTOBER' named entity 'BACTERIA ' named entity '2.2' named entity 'INFLUENZA' named entity 'TREATMENT' named entity 'UPPER RESPIRATORY TRACT' named entity 'pneumonia' named entity 'respiratory' named entity 'rSV' named entity 'cases' named entity 'immunisation' named entity '95% ci' named entity 'strategies' named entity 'australian' named entity 'VIRUSES' named entity 'HEALTHY' named entity 'DETERMINE' named entity 'THEIR' named entity 'CASES' named entity 'ESTIMATED' named entity 'LOCAL' named entity 'CONTRIBUTION' named entity 'CASE-CONTROL STUDY' named entity 'COMMON' named entity 'PNEUMONIA' named entity 'RESPONSIBLE' named entity 'RESPIRATORY SYNCYTIAL VIRUS' named entity 'VACCINATED' named entity 'COMMUNITY-ACQUIRED PNEUMONIA' named entity 'CHILDREN' named entity 'FRACTION' named entity 'DIFFICULT' named entity 'AUSTRALIAN' named entity 'ADJUSTING' named entity 'SWABS' named entity '6.2' named entity '2015' named entity 'PERTH' named entity '80%' named entity 'PREVENTIVE STRATEGIES' named entity 'ATTRIBUTABLE' named entity 'MAJOR'

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