About: Porcine bocavirus NP1 negatively regulates interferon signaling pathway by targeting the DNA-binding domain of IRF9

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Porcine bocavirus NP1 negatively regulates interferon signaling pathway by targeting the DNA-binding domain of IRF9 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Porcine bocavirus NP1 negatively regulates interferon signaling pathway by targeting the DNA-binding domain of IRF9
Creator	Chen, Huanchun Li, Yi Zhang, Huan Fang, Liurong Wang, Dang Xiao, Shaobo Cai, Kaimei Xie, Lilan Zhang, Ruoxi
Source	Elsevier; Medline; PMC
abstract	Abstract To subvert host antiviral immune responses, many viruses have evolved countermeasures to inhibit IFN signaling pathway. Porcine bocavirus (PBoV), a newly identified porcine parvovirus, has received attention because it shows clinically high co-infection prevalence with other pathogens in post-weaning multisystemic wasting syndrome (PWMS) and diarrheic piglets. In this study, we screened the structural and non-structural proteins encoded by PBoV and found that the non-structural protein NP1 significantly suppressed IFN-stimulated response element (ISRE) activity and subsequent IFN-stimulated gene (ISG) expression. However, NP1 affected neither the activation and translocation of STAT1/STAT2, nor the formation of the heterotrimeric transcription factor complex ISGF3 (STAT1/STAT2/IRF9). Detailed analysis demonstrated that PBoV NP1 blocked the ISGF3 DNA-binding activity by combining with the DNA-binding domain (DBD) of IRF9. In summary, these results indicate that PBoV NP1 interferes with type I IFN signaling pathway by blocking DNA binding of ISGF3 to attenuate innate immune responses.
has issue date	2015-11-30(xsd:dateTime)
bibo:doi	10.1016/j.virol.2015.08.005
bibo:pmid	26342467
has license	els-covid
sha1sum (hex)	b4f9207d49147ef1be839aa08adbfec11b7e46d4
schema:url	https://doi.org/10.1016/j.virol.2015.08.005
resource representing a document's title	Porcine bocavirus NP1 negatively regulates interferon signaling pathway by targeting the DNA-binding domain of IRF9
has PubMed Central identifier	PMC7111627
has PubMed identifier	26342467
schema:publication	Virology
resource representing a document's body	covid:b4f9207d49147ef1be839aa08adbfec11b7e46d4#body_text
is schema:about of	named entity 'transcription factor' named entity 'IFN' named entity 'TARGETING' named entity 'ENCODED' named entity 'FOUND' named entity 'NEWLY' named entity 'TRANSLOCATION' named entity 'IMMUNE RESPONSES' named entity 'EXPRESSION' named entity 'BINDING' named entity 'TRANSCRIPTION FACTOR COMPLEX' named entity 'SIGNALING PATHWAY' named entity 'RESPONSE ELEMENT' named entity 'IDENTIFIED' named entity 'RECEIVED' named entity 'PATHOGENS' named entity 'EVOLVED' named entity 'GENE' named entity 'BINDING' named entity 'NEITHER' named entity 'PORCINE PARVOVIRUS' named entity 'CO-INFECTION' named entity 'DNA BINDING' named entity 'STRUCTURAL PROTEIN' named entity 'BLOCKING' named entity 'DOMAIN' named entity 'DETAILED' named entity 'ATTENTION' named entity 'NON-' named entity 'NP1' named entity 'DNA' named entity 'PORCINE BOCAVIRUS' named entity 'IRF9' named entity 'SIGNALING PATHWAY' named entity 'INTERFERES WITH' named entity 'NP1' named entity 'PORCINE BOCAVIRUS' named entity 'ATTENUATE' named entity 'COMBINING' named entity 'POSTWEANING MULTISYSTEMIC WASTING SYNDROME' named entity 'FORMATION' named entity 'STUDY' named entity 'INTERFERON SIGNALING' named entity 'ANALYSIS' named entity 'ISGF3' named entity 'HOST' named entity 'AFFECTED' named entity 'STAT1' named entity 'IFN' named entity 'BINDING ACTIVITY' named entity 'WITH TYPE' named entity 'STRUCTURAL' named entity 'DOMAIN' named entity 'TO INHIBIT' named entity 'HAVE' named entity 'TYPE I' named entity 'STIMULATED' named entity 'THESE' named entity 'RESULTS' named entity 'INFECTION PREVALENCE' named entity 'SUBSEQUENT' named entity 'DNA' named entity 'BLOCKED' named entity 'IRF9' named entity 'SUMMARY' named entity 'ACTIVATION' named entity 'SUPPRESSED' named entity 'VIRUSES' named entity 'ANTIVIRAL' named entity 'PROTEIN ' named entity 'NON-STRUCTURAL PROTEINS' named entity 'ACTIVITY' named entity 'HIGH'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software