About: Inhaled nitric oxide as an adjunct to neonatal resuscitation in premature infants: a pilot, double blind, randomized controlled trial

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About: Inhaled nitric oxide as an adjunct to neonatal resuscitation in premature infants: a pilot, double blind, randomized controlled trial Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Inhaled nitric oxide as an adjunct to neonatal resuscitation in premature infants: a pilot, double blind, randomized controlled trial
Creator	Szyld, Edgardo Anderson, Michael Lakshminrusimha, Satyan Dannaway, Douglas Helmbrecht, Ashley Manfredo, Amy Mccoy, Michael Noori, Shahab Riley, Julee Sekar, Krishnamurthy Wlodaver, Anne
Source	PMC
abstract	BACKGROUND: Nitric oxide (NO) plays an important role in normal postnatal transition. Our aims were to determine whether adding inhaled NO (iNO) decreases supplemental oxygen exposure in preterm infants requiring positive pressure ventilation (PPV) during resuscitation and to study iNO effects on heart rate (HR), oxygen saturation (SpO(2)), and need for intubation during the first 20 min of life. METHODS: This was a pilot, double-blind, randomized, placebo-controlled trial. Infants 25 0/7–31 6/7 weeks’ gestational age requiring PPV with supplemental oxygen during resuscitation were enrolled. PPV was initiated with either oxygen (FiO(2)–0.30) + iNO at 20 ppm (iNO group) or oxygen (FiO(2)–0.30) + nitrogen (placebo group). Oxygen was titrated targeting defined SpO(2) per current guidelines. After 10 min, iNO/nitrogen was weaned stepwise per protocol and terminated at 17 min. RESULTS: Twenty-eight infants were studied (14 per group). The mean gestational age in both groups was similar. Cumulative FiO(2) and rate of exposure to high FiO(2) (>0.60) were significantly lower in the iNO group. There were no differences in HR, SpO(2), and need for intubation. CONCLUSIONS: Administration of iNO as an adjunct during neonatal resuscitation is feasible without side effects. It diminishes exposure to high levels of supplemental oxygen.
has issue date	2019-10-30(xsd:dateTime)
bibo:doi	10.1038/s41390-019-0643-x
bibo:pmid	31666688
has license	no-cc
sha1sum (hex)	b4c8b0bbe8560c90a4a1d7abf7a6940911bcad69
schema:url	https://doi.org/10.1038/s41390-019-0643-x
resource representing a document's title	Inhaled nitric oxide as an adjunct to neonatal resuscitation in premature infants: a pilot, double blind, randomized controlled trial
has PubMed Central identifier	PMC7223624
has PubMed identifier	31666688
schema:publication	Pediatr Res
resource representing a document's body	covid:b4c8b0bbe8560c90a4a1d7abf7a6940911bcad69#body_text
is schema:about of	named entity 'Oxygen' named entity 'Nitric oxide' named entity 'resuscitation' named entity 'positive pressure ventilation' named entity 'heart rate' named entity 'gestational age' named entity 'adjunct' named entity 'INTUBATION' named entity 'POSITIVE PRESSURE VENTILATION' named entity 'INHALED' named entity 'SIDE EFFECTS' named entity 'PILOT' named entity 'FEASIBLE' covid:arg/b4c8b0bbe8560c90a4a1d7abf7a6940911bcad69 named entity 'iNO' named entity 'iNO' named entity 'iNO' named entity 'study' named entity 'preterm' named entity 'PPV' named entity 'current' named entity 'oxygen saturation' named entity 'ppm' named entity 'supplemental oxygen' named entity 'gestational age' named entity 'iNO' named entity 'iNO' named entity 'postnatal' named entity 'placebo group' named entity 'resuscitation' named entity 'oxygen' named entity 'supplemental oxygen' named entity 'intubation' named entity 'nitric oxide' named entity 'double blind' named entity 'oxygen' named entity 'oxygen' named entity 'pulmonary vascular resistance' named entity 'iNO' named entity 'iNO' named entity 'intubation' named entity 'surfactant' named entity 'iNO' named entity 'ventilation perfusion mismatch' named entity 'placebo' named entity 'oxygen' named entity 'vasodilator' named entity 'positive pressure ventilation' named entity 'high levels' named entity 'lungs' named entity 'iNO' named entity 'Institutional Review Board' named entity 'neonatal resuscitation' named entity 'fetal' named entity 'nitric oxide' named entity 'Oxygen administration' named entity 'beats per minute' named entity 'placebo' named entity 'ppm' named entity '100% oxygen' named entity 'iNO' named entity 'Masimo' named entity 'pulmonary hypertension' named entity 'informed consent' named entity 'iNO' named entity 'vasodilator' named entity 'continuous positive airway pressure' named entity 'placebo' named entity 'premature infants' named entity 'placebo group' named entity 'premature infants'

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