About: EasyCOV : LAMP based rapid detection of SARS-CoV-2 in saliva

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About: EasyCOV : LAMP based rapid detection of SARS-CoV-2 in saliva Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	EasyCOV : LAMP based rapid detection of SARS-CoV-2 in saliva
Creator	Foulongne, Vincent Galtier, Florence Reynes, Jacques Alali, Mellis Baptiste, Julie Cardeur, Lise Champigneux, Pierre Dubuc, Benjamin Espeut, Julien L'helgouach, Nicolas Makinson, Alain Marin, Grégory Molina, Franck Molina, Laurence Picot, Marie-Christine Prieux-Lejeune, Alexandra Quenot, Marine Robles, Francisco Salvetat, Nicolas Santos Schneider, Francisco Vetter, Diana
source	MedRxiv
abstract	Covid-19 crisis showed us that rapid massive virus detection campaign is a key element in SARS-CoV-2 pandemic response. The classical RT-PCR laboratory platforms must be complemented with rapid and simplified technologies to enhance efficiency of large testing strategies. To this aim, we developed EasyCoV, a direct saliva RT-LAMP based SARS-CoV-2 virus detection assay that do not requires any RNA extraction step. It allows robust and rapid response under safe and easy conditions for healthcare workers and patients. EasyCov test was assessed under double blind clinical conditions (93 asymptomatic healthcare worker volonteers, 10 actively infected patients, 20 former infected patients tested during late control visit). EasyCov results were compared with classical laboratory RT-PCR performed on nasopharyngeal samples. Our results show that compared with nasopharyngeal laboratory RT-PCR, EasyCov SARS-CoV-2 detection test has a sensitivity of 72.7%. Measured on healthcare worker population the specificity was 95.7%. LAMP technology on saliva is clearly able to identify subjects with infectivity profile. Among healthcare worker population Easycov test detected one presymptomatic subject. Because it is simple, rapid and painless for patients, EasyCov saliva SARS-Cov-2 detection test may be useful for large screening of general population.
has issue date	2020-05-30(xsd:dateTime)
bibo:doi	10.1101/2020.05.30.20117291
has license	medrxiv
sha1sum (hex)	b4b226578862a7eaaf4abf0b07116d471cc04bbd
schema:url	https://doi.org/10.1101/2020.05.30.20117291
resource representing a document's title	EasyCOV : LAMP based rapid detection of SARS-CoV-2 in saliva
resource representing a document's body	covid:b4b226578862a7eaaf4abf0b07116d471cc04bbd#body_text
is schema:about of	named entity 'Covid-19' named entity 'pandemic' named entity 'MASSIVE' named entity 'RAPID' named entity 'TECHNOLOGIES' named entity 'CRISIS' named entity 'CLASSICAL' named entity 'IS A' named entity 'simplified' named entity 'testing' named entity 'technologies' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity 'RT-PCR' named entity 'SARS-CoV-2' named entity 'healthcare workers' named entity 'cross-reacting' named entity 'false positive' named entity 'saliva' named entity 'false positive' named entity 'nasopharyngeal' named entity 'RNA extraction' named entity '2019-nCoV' named entity 'healthcare workers' named entity 'serology' named entity 'H2O' named entity 'saliva' named entity 'RNA extraction' named entity 'socio-economics' named entity 'laboratory analysis' named entity 'transport medium' named entity 'SARS-CoV-2 virus' named entity 'clinical samples' named entity 'saliva' named entity 'DTT' named entity 'clinical study' named entity 'saliva' named entity 'Saliva' named entity 'negative result' named entity 'false positive results' named entity 'virus' named entity 'healthcare workers' named entity 'RNA' named entity 'Qiagen' named entity 'virus' named entity 'antigen' named entity 'pipette' named entity 'RT-PCR' named entity 'Contingency table' named entity 'potentially infectious' named entity 'CC-BY-ND' named entity 'SARS-CoV-2 virus' named entity 'DNA amplification' named entity 'RT-PCR' named entity '2019-nCoV' named entity 'Lysis buffer' named entity 'open source Software' named entity 'tropism' named entity 'SARS-CoV-2' named entity 'RT-PCR' named entity 'infection' named entity 'Healthcare workers' named entity 'infection' named entity 'SARS-CoV-2' named entity 'medRxiv'

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