About: Increased levels of myelin basic protein transcripts gene in virus-induced demyelination

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About: Increased levels of myelin basic protein transcripts gene in virus-induced demyelination Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Increased levels of myelin basic protein transcripts gene in virus-induced demyelination
Creator	Ahmann, G Andrysiak, P Barnes, M Bemacerraf, B Bevan, M Burakoft, S Fink, P Germain, R Immun, Kruisbeek, A Lmmun ; H-G, Pettinelli, C Rock, K Schaefer, M Shearer, G Shevach, E Singer, A Sprent, J Swain, S Thomas, D Yamashita, U
Source	Medline; PMC
abstract	In multiple sclerosis, a demyelinating disease of young adults, there is a paucity of myelin repair in the central nervous system (CNS) which is necessary for the restoration of fast saltatory conduction in axons(1,2). Consequently, this relapsing disease often causes marked disability. In similar diseases of small rodents, however, remyelination can be quite extensive, as in the demyelinating disease caused by the A59 strain of mouse hepatitis virus (MHV-A59)(3,4), a coronavirus of mice. To investigate when and where oligodendrocytes are first triggered to repair CNS myelin in such disease, we have used a complementary DNA probe specific for one major myelin protein gene, myelin basic protein (MBP), which hybridizes with the four forms of MBP messenger RNA in rodents(5). Using Northern blot and in situ hybridization techniques, we previously found that MBP mRNA is first detected at about 5 days after birth, peaks at 18 days and progressively decreases to 25% of the peak levels in the adult(5–7). We now report that in spinal cord sections of adult animals with active demyelination and inflammatory cells, in situ hybridization reveals a dramatic increase in probe binding to MBP-specific mRNA at (2–3) weeks after virus inoculation and before remyelination can be detected by morphological methods. This increase of MBP-specific mRNA is found at the edge of the demyelinating area and extends into surrounding areas of normal-appearing white matter. Thus, in situ hybridization with myelin-specific probes appears to be a useful method for detecting the timing, intensity and location of myelin protein gene reactivation preceding remyelination. This method could be used to elucidate whether such a reactivation occurs in multiple sclerosis brain tissue. Our results suggest that in mice, glial cells react to a demyelinating process with widespread MBP mRNA synthesis which may be triggered by a diffusible factor released in the demyelinated areas.
has issue date	1986-01-01(xsd:dateTime)
bibo:doi	10.1038/322544a0
bibo:pmid	2426599
has license	no-cc
sha1sum (hex)	b497b7214952238c55e0835f00cb61eacb0d0590
schema:url	https://doi.org/10.1038/322544a0
resource representing a document's title	Increased levels of myelin basic protein transcripts gene in virus-induced demyelination
has PubMed Central identifier	PMC7095299
has PubMed identifier	2426599
schema:publication	Nature
resource representing a document's body	covid:b497b7214952238c55e0835f00cb61eacb0d0590#body_text
is schema:about of	named entity 'irradiated' named entity 'antigens' named entity 'transcripts' named entity 'GENE' named entity 'L3T4' named entity 'LYT-2' named entity 'H-2 ANTIGENS' named entity 'IMMUNOGENIC' named entity 'IRRADIATED' named entity 'HAVE' named entity 'UNPRIMED' named entity 'RESPECT' named entity 'MYELIN BASIC PROTEIN' named entity 'VIRUS' named entity 'POSSIBLE' named entity 'CELLS' named entity 'MIXING' named entity 'SUBCUTANEOUS' named entity 'GROWTH' named entity 'P815' named entity 'PRELIMINARY' named entity 'INDUCED' named entity 'INCREASED' named entity 'PROTEIN ' named entity 'DEMYELINATION' named entity 'TUMOURS' named entity 'TUMOUR CELLS' named entity 'LEVELS' named entity 'TRANSCRIPTS' named entity 'PURIFIED' named entity 'EVIDENCE' named entity 'TUMOUR' named entity 'BEING' named entity 'MICE' named entity 'INVOLVEMENT' named entity 'REJECTION' named entity 'DATA' named entity 'IN VIVO' named entity 'DIRECTLY' covid:arg/b497b7214952238c55e0835f00cb61eacb0d0590 named entity 'mice' named entity 'processed' named entity 'immunogenic' named entity 'mice' named entity 'immunocytochemistry' named entity 'MBP' named entity 'remyelination' named entity 'proteolysis' named entity 'demyelination' named entity 'mRNA synthesis' named entity 'virus' named entity 'rodents' named entity 'chondrocytes' named entity 'interferons' named entity 'cytokine' named entity 'TNF' named entity 'CNS' named entity 'proteoglycan' named entity 'peroxidase' named entity 'porcine' named entity 'remyelination'

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