About: Successful cross-protective efficacy induced by heat-adapted live attenuated nephropathogenic infectious bronchitis virus derived from a natural recombinant strain

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About: Successful cross-protective efficacy induced by heat-adapted live attenuated nephropathogenic infectious bronchitis virus derived from a natural recombinant strain Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Successful cross-protective efficacy induced by heat-adapted live attenuated nephropathogenic infectious bronchitis virus derived from a natural recombinant strain
Creator	Lee, Joong-Bok Lim, Tae-Hyun Song, Chang-Seon Youn, Ha-Na Lee, Sang-Won Gwon, Gyeong-Bin Hong, Woo-Tack Kwon, Jung-Hoon Lee, Jung-Ah Yuk, Seong-Su
topic	covid:b4670d1961a9652df5363d430e76eb4b9f729b6b#this
source	Elsevier; Medline; PMC
abstract	Abstract A natural recombinant nephropathogenic K40/09 strain of infectious bronchitis virus (IBV) was heat-adapted for possible future use as live attenuated vaccine. The K40/09 strain was selected during successive serial passages in specific-pathogen free (SPF) embryonated eggs at sub-optimal higher temperature (56°C). Unlike the parental strain, the attenuated strain, designated K40/09 HP50, was found to be safe in 1-day-old SPF chicks, which showed neither mortality nor signs of morbidity, and rarely induced ciliostasis or histological changes in the trachea and kidney after intraocular and fine-spray administration. K40/09 HP50 provided almost complete protection against two distinct subgroups of a nephropathogenic strain (KM91-like and QX-like subgroup) and elicited the production of high titers of neutralizing antibody (neutralization index of 3.6). We conclude that the K40/09 HP50 vaccine virus is rapidly attenuated by heat adaptation and exhibits the desired level of attenuation, immunogenicity, and protective efficacy required for a live attenuated vaccine. These results indicate that the K40/09 vaccine could be helpful for the reduction of economic losses caused by recently emergent nephropathogenic IBV infection in many countries.
has issue date	2015-12-16(xsd:dateTime)
bibo:doi	10.1016/j.vaccine.2015.07.043
bibo:pmid	26218899
has license	els-covid
sha1sum (hex)	b4670d1961a9652df5363d430e76eb4b9f729b6b
schema:url	https://doi.org/10.1016/j.vaccine.2015.07.043
resource representing a document's title	Successful cross-protective efficacy induced by heat-adapted live attenuated nephropathogenic infectious bronchitis virus derived from a natural recombinant strain
has PubMed Central identifier	PMC7130781
has PubMed identifier	26218899
schema:publication	Vaccine
resource representing a document's body	covid:b4670d1961a9652df5363d430e76eb4b9f729b6b#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/b4670d1961a9652df5363d430e76eb4b9f729b6b
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