About: Prediction of non-canonical routes for SARS-CoV-2 infection in human placenta cells

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About: Prediction of non-canonical routes for SARS-CoV-2 infection in human placenta cells Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Prediction of non-canonical routes for SARS-CoV-2 infection in human placenta cells
Creator	Affiliations, Carvalho, Carvalho, R Constantino, F Cury, S Justulin, L Justulin, Luis Nogueira, C Robson, Francisco
Source	BioRxiv
abstract	The SARS-CoV-2 is the causative agent of the COVID-19 pandemic. The data available about COVID-19 during pregnancy have demonstrated placental infection; however, the intrauterine transmission of SARS-CoV-2 is still debated. Intriguingly, while canonical SARS-CoV-2 cell entry mediators are expressed at low levels in placental cells, the receptors for viruses that cause congenital infections such as the cytomegalovirus and Zika virus are highly expressed in these cells. Here we analyzed the transcriptional profile (microarray and single-cell RNA-Seq) of proteins potentially interacting with coronaviruses to identify non-canonical mediators of SARS-CoV-2 infection and replication in the placenta. We show that, despite low levels of the canonical cell entry mediators ACE2 and TMPRSS2, cells of the syncytiotrophoblast, villous cytotrophoblast, and extravillous trophoblast co-express high levels of the potential non-canonical cell-entry mediators DPP4 and CTSL. We also found changes in the expression of DAAM1 and PAICS genes during pregnancy, which are translated into proteins also predicted to interact with coronaviruses proteins. These results provide new insight into the interaction between SARS-CoV-2 and host proteins that may act as non-canonical routes for SARS-CoV-2 infection and replication in the placenta cells.
has issue date	2020-08-13(xsd:dateTime)
bibo:doi	10.1101/2020.06.12.148411
has license	biorxiv
sha1sum (hex)	b438f159c5ef3ee64d0256940c8e72159c415e59
schema:url	https://doi.org/10.1101/2020.06.12.148411
resource representing a document's title	Prediction of non-canonical routes for SARS-CoV-2 infection in human placenta cells
schema:publication	bioRxiv
resource representing a document's body	covid:b438f159c5ef3ee64d0256940c8e72159c415e59#body_text
is schema:about of	named entity 'levels' named entity 'pandemic' named entity 'mediators' named entity 'trophoblast' named entity 'cell' named entity 'SARS-CoV-2' named entity 'infection' named entity 'PLACENTAL INFECTION' named entity 'placental' named entity 'levels' named entity 'SARS-CoV-2' named entity 'RNA-Seq' named entity 'cytomegalovirus' named entity 'causative' named entity 'demonstrated' named entity 'cells' named entity 'high' named entity 'SARS-CoV-2' named entity 'Title' named entity 'TMPRSS2' named entity 'causative agent' named entity 'high levels' named entity 'ACE2' named entity 'SARS-CoV-2' named entity 'placental' named entity 'COVID-19' named entity 'Zika' named entity 'infection' named entity 'placental' named entity 'infection' named entity 'infection' named entity 'DPP4' named entity 'COVID' named entity 'China' named entity 'cytotrophoblast' named entity 'protein' named entity 'non-structural proteins' named entity 'brain damage' named entity 'SARS-CoV-2' named entity 'purine biosynthesis pathway' named entity 'SARS-CoV-2' named entity 'TMPRSS2' named entity 'IgG' named entity 'DPP4' named entity 'SARS-CoV' named entity 'neonatal' named entity 'cell division' named entity 'infection' named entity 'virus' named entity 'vesicles' named entity 'DAAM1' named entity 'fetal cells' named entity 'PID' named entity 'intracellular' named entity 'cellular membranes' named entity 'SARS-CoV-2' named entity 'PAICS' named entity 'cell entry' named entity 'interact' named entity 'immunoglobulin' named entity 'ACE2' named entity 'SARS-CoV-2' named entity 'liver' named entity 'pregnant women' named entity 'trophoblast cells' named entity 'placenta' named entity 'COVID' named entity 'SARS-CoV-2' named entity 'ACE2' named entity 'PAICS' named entity 'expression profile' named entity 'cornea' named entity 'asymptomatic' named entity 'cell entry' named entity 'placental' named entity 'interact'

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