About: High SARS-CoV-2 Seroprevalence in Children and Adults in the Austrian Ski Resort Ischgl

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About: High SARS-CoV-2 Seroprevalence in Children and Adults in the Austrian Ski Resort Ischgl Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	High SARS-CoV-2 Seroprevalence in Children and Adults in the Austrian Ski Resort Ischgl
Creator	Borena, Wegene Von Laer, Dorothee Bandyopadhyay, Arnab Bates, Katie Binder, Sebastian Btech, Falkensammer, Barbara Kimpel, Janine Knabl, Ludwig Meyer-Hermann, Michael Mitra, Tanmay Pipperger, Lisa Ranjan, Mrinalini Riepler, Lydia Rössler, Annika Schips, Marta Ulmer, Hanno Volland, André Walser, Andreas
Source	MedRxiv
abstract	Background: Early March 2020, a SARS-CoV-2 outbreak in the ski resort Ischgl in Austria initiated the spread of SARS-CoV-2 throughout Austria and Northern Europe. Methods: Between April 21 and 27, a cross-sectional epidemiologic study targeting the full population of Ischgl (n= 1867), of which 79% could be included (n=1473, incl. 214 children), was performed. For each individual, the study involved a SARS-CoV-2 PCR, antibody testing and structured questionnaires. A mathematical model was used to help understand the influence of the determined seroprevalence on virus transmission. Findings: The seroprevalence was 42.4% (95% CI 39.8-44.7). Individuals under 18 showed a significantly lower seroprevalence of 27.1% (95% CI 21.3-33.6) than adults (45%; 95% CI 42.2-47.7; OR of 0.455, 95% CI 0.356-0.682, p<0.001). Of the seropositive individuals, 83.7% had not been diagnosed to have had SARS-CoV-2 infection previously. The clinical course was generally mild. Over the previous two months, two COVID-19-related deaths had been recorded, corresponding to an infection fatality rate (IFR) of 0.25% (95% CI 0.03-0.91). Only 8 (0.5 %) individuals were newly diagnosed to be infected with SARS-CoV-2 during this study. Interpretation: Ischgl was hit early and hard by SARS-CoV-2 leading to a high local seroprevalence of 42.4%, which was lower in individuals below the age of 18 than in adults. Mathematical modeling suggests that a drastic decline of newly infected individuals in Ischgl by the end of April occured due to the dual impact from the non-pharmacological interventions (NPIs) and a significant immunization of the Ischgl population. Funding: Helmholtz Association, European Union's Horizon 2020 research and innovation program, German Research Foundation (DFG), state Tyrol.
has issue date	2020-08-22(xsd:dateTime)
bibo:doi	10.1101/2020.08.20.20178533
has license	medrxiv
sha1sum (hex)	b41e285efeaf6e5ca834c7011f90fc2b5cbc062b
schema:url	https://doi.org/10.1101/2020.08.20.20178533
resource representing a document's title	High SARS-CoV-2 Seroprevalence in Children and Adults in the Austrian Ski Resort Ischgl
resource representing a document's body	covid:b41e285efeaf6e5ca834c7011f90fc2b5cbc062b#body_text
is schema:about of	named entity 'reading' named entity 'antibody testing' named entity 'Ischgl' named entity 'robustness' named entity 'preprint' named entity '1473' named entity 'performed' named entity 'SARS-CoV-2' named entity 'SARS-COV-2' named entity 'immunization' named entity 'COVID-19' named entity 'IFR' named entity 'Austria' named entity 'mathematical analysis' named entity 'mild' named entity 'SARS-CoV-2' named entity 'infected' named entity 'generally' named entity 'individuals' named entity 'Interpretation' named entity 'structured' named entity 'critically' named entity '95% CI' named entity 'ski resort' named entity 'infection' named entity 'Ischgl' named entity 'Austria' named entity 'SARS-CoV-2' named entity 'Austria' named entity 'SARS-CoV-2' named entity 'immunization' named entity 'COVID' named entity 'Ischgl' named entity 'anosmia' named entity 'Ischgl' named entity 'antibody' named entity 'viral RNA' named entity 'super-spreading' named entity 'SARS-CoV-2' named entity 'super-spreading' named entity 'Iceland' named entity 'seroprevalence' named entity 'ski resort' named entity 'SARS-CoV-2 outbreak' named entity 'Ischgl' named entity 'IgG' named entity 'Ischgl' named entity 'PCR' named entity 'anosmia' named entity 'Ischgl' named entity 'Ischgl' named entity '95% CI' named entity 'guest workers' named entity 'PCR testing' named entity 'peer review' named entity 'seropositivity' named entity 'COVID-19' named entity 'Loss of smell' named entity 'COVID-19' named entity 'seroprevalence' named entity 'SARS-CoV-2' named entity 'official data' named entity 'peer review' named entity 'infection' named entity 'March 20' named entity 'seroprevalence' named entity 'PCR'

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