About: Using random testing in a feedback-control loop to manage a safe exit from the COVID-19 lockdown

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Using random testing in a feedback-control loop to manage a safe exit from the COVID-19 lockdown
Creator	Müller, Markus Aeppli, Gabriel Derlet, Peter Mudry, Christopher
Source	MedRxiv
abstract	We argue that frequent sampling of the fraction of infected people (either by random testing or by analysis of sewage water), is central to managing the COVID-19 pandemic because it both measures in real time the key variable controlled by restrictive measures, and anticipates the load on the healthcare system due to progression of the disease. Knowledge of random testing outcomes will (i) significantly improve the predictability of the pandemic, (ii) allow informed and optimized decisions on how to modify restrictive measures, with much shorter delay times than the present ones, and (iii) enable the real-time assessment of the efficiency of new means to reduce transmission rates. Here we suggest, irrespective of the size of a suitably homogeneous population, a conservative estimate of 15000 for the number of randomly tested people per day which will suffice to obtain reliable data about the current fraction of infections and its evolution in time, thus enabling close to real-time assessment of the quantitative effect of restrictive measures. Still higher testing capacity permits detection of geographical differences in spreading rates. Furthermore and most importantly, with daily sampling in place, a reboot could be attempted while the fraction of infected people is still an order of magnitude higher than the level required for a relaxation of restrictions with testing focused on symptomatic individuals. This is demonstrated by considering a feedback and control model of mitigation where the feed-back is derived from noisy sampling data.
has issue date	2020-04-14(xsd:dateTime)
bibo:doi	10.1101/2020.04.09.20059360
has license	medrxiv
sha1sum (hex)	b4067dfad4918e578726b43965ccb217df035d36
schema:url	https://doi.org/10.1101/2020.04.09.20059360
resource representing a document's title	Using random testing in a feedback-control loop to manage a safe exit from the COVID-19 lockdown
resource representing a document's body	covid:b4067dfad4918e578726b43965ccb217df035d36#body_text
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