About: Type I interferon receptor knockout mice as models for infection of highly pathogenic viruses with outbreak potential

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About: Type I interferon receptor knockout mice as models for infection of highly pathogenic viruses with outbreak potential Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Type I interferon receptor knockout mice as models for infection of highly pathogenic viruses with outbreak potential
Creator	Wong, Gary Qiu, Xiang-Guo
topic	covid:b2ffe7f0bedb7b3ab6d0181ec70ece3e4e2dabea#this
Source	Medline; PMC
abstract	Due to their inability to generate a complete immune response, mice knockout for type I interferon (IFN) receptors (Ifnar(–/–)) are more susceptible to viral infections, and are thus commonly used for pathogenesis studies. This mouse model has been used to study many diseases caused by highly pathogenic viruses from many families, including the Flaviviridae, Filoviridae, Arenaviridae, Bunyaviridae, Henipaviridae, and Togaviridae. In this review, we summarize the findings from these animal studies, and discuss the pros and cons of using this model versus other known methods for studying pathogenesis in animals.
has issue date	2018-02-09(xsd:dateTime)
bibo:doi	10.24272/j.issn.2095-8137.2017.052
bibo:pmid	29511140
has license	cc-by
sha1sum (hex)	b2ffe7f0bedb7b3ab6d0181ec70ece3e4e2dabea
schema:url	https://doi.org/10.24272/j.issn.2095-8137.2017.052
resource representing a document's title	Type I interferon receptor knockout mice as models for infection of highly pathogenic viruses with outbreak potential
has PubMed Central identifier	PMC5869239
has PubMed identifier	29511140
schema:publication	Zool Res
resource representing a document's body	covid:b2ffe7f0bedb7b3ab6d0181ec70ece3e4e2dabea#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/b2ffe7f0bedb7b3ab6d0181ec70ece3e4e2dabea
is schema:about of	named entity 'Due' named entity 'susceptible' named entity 'viral infections' named entity 'INFECTION' named entity 'INTERFERON ' named entity 'PATHOGENIC' named entity 'USED' named entity 'VIRAL INFECTIONS' named entity 'DISCUSS' named entity 'STUDIES' named entity 'IMMUNE RESPONSE' named entity 'REVIEW' named entity 'TYPE I INTERFERON' named entity 'RECEPTORS' named entity 'MODEL' named entity 'FAMILIES' named entity 'COMPLETE' named entity 'FINDINGS' named entity 'TOGAVIRIDAE' named entity 'DISEASES' named entity 'HIGHLY' named entity 'BUNYAVIRIDAE' named entity 'VIRUSES' named entity 'GENERATE' named entity 'MICE' named entity 'KNOCKOUT MICE' named entity 'MODELS' named entity 'TYPE I INTERFERON RECEPTOR' named entity 'METHODS' named entity 'PROS AND CONS' named entity 'HIGHLY' named entity 'THESE' named entity 'DUE TO' named entity 'PATHOGENIC' named entity 'POTENTIAL' named entity 'OUTBREAK' named entity 'VIRUSES' named entity 'KNOWN' named entity 'KNOCKOUT' named entity 'PATHOGENESIS' named entity 'ARENAVIRIDAE' named entity 'INCLUDING' named entity 'FILOVIRIDAE' named entity 'THEIR' named entity 'MOUSE MODEL' named entity 'ANIMALS' named entity 'FLAVIVIRIDAE' named entity 'USING' named entity 'CAUSED BY' named entity 'STUDY' named entity 'INABILITY' named entity 'ANIMAL STUDIES' named entity 'SUSCEPTIBLE' named entity 'Bunyaviridae' named entity 'cons' named entity 'outbreak' named entity 'Ifnar' named entity 'mice' named entity 'Flaviviridae' named entity 'pathogenesis' named entity 'pathogenesis' named entity 'infection' named entity 'receptor' named entity 'Type I interferon' named entity 'diseases' named entity 'endemic' named entity 'liver' named entity 'Mastomys natalensis' named entity 'morbidity' named entity 'high levels' named entity 'neuroinvasive' named entity 'immune responses' named entity 'virus' named entity 'vaccinia virus' named entity 'wild-type' named entity 'CFR' named entity 'liver failure' named entity 'infection'

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