About: Functional Involvement of Interferon-Inducible Transmembrane Proteins in Antiviral Immunity

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About: Functional Involvement of Interferon-Inducible Transmembrane Proteins in Antiviral Immunity Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Functional Involvement of Interferon-Inducible Transmembrane Proteins in Antiviral Immunity
Creator	Liang, Chen Chen, Ji-Long Chiu, Shih-Hsin Liao, Yuan Yuan, Xu Zhang, Baoge Liao, Y De Andrea, Marco Mu, Goraya Ullah Goraya, Mohsan
Source	Medline; PMC
abstract	Interferons (IFNs) play crucial roles in host defense against viral infections by inducing the expression of numerous IFN-stimulated genes (ISGs) that can activate host antiviral immunity. Interferon-inducible transmembrane proteins (IFITMs), a family of small transmembrane proteins, are critical ISG products. Compelling evidence has implicated that IFITMs can establish an innate immune state to eliminate pathogens efficiently. IFITM proteins can impede broad-spectrum viral infection through various mechanisms. It is generally believed that IFITMs can block the viral entry by suppressing viral membrane fusion. However, some findings indicated that IFITMs might also inhibit viral gene expression and viral protein synthesis and thereby impair viral replication. IFITMs may incorporate into virions during viral assembly and thus reduce the infectivity of nascent virions. The precise inhibitory mechanism of IFITMs on viral infection and replication still requires further exploration. In this review, we highlight the recent findings regarding critical roles of IFITMs in host-virus interaction. We also discuss the molecular mechanisms underlying their functions in antiviral responses.
has issue date	2019-05-16(xsd:dateTime)
bibo:doi	10.3389/fmicb.2019.01097
bibo:pmid	31156602
has license	cc-by
sha1sum (hex)	b2d7e294cc9cffc5de442aef23ef615f70e3c746
schema:url	https://doi.org/10.3389/fmicb.2019.01097
resource representing a document's title	Functional Involvement of Interferon-Inducible Transmembrane Proteins in Antiviral Immunity
has PubMed Central identifier	PMC6532022
has PubMed identifier	31156602
schema:publication	Front Microbiol
resource representing a document's body	covid:b2d7e294cc9cffc5de442aef23ef615f70e3c746#body_text
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