About: Conserved tertiary structure elements in the 5′ untranslated region of human enteroviruses and rhinoviruses

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About: Conserved tertiary structure elements in the 5′ untranslated region of human enteroviruses and rhinoviruses Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Conserved tertiary structure elements in the 5′ untranslated region of human enteroviruses and rhinoviruses
Creator	Sonenberg, Nahum Chen, Jih-H Le,', Shu-Yun Maizel, Jacob
Source	Elsevier; Medline; PMC
abstract	Abstract A combination of comparative sequence analysis and thermodynamic methods reveals the conservation of tertiary structure elements in the 5′ untranslated region (UTR) of human enteroviruses and rhinoviruses. The predicted common structural elements occur in the 3′ end of a segment that is critical for internal ribosome binding, termed “ribosome landing pad” (RLP), of polioviruses. Base pairings between highly conserved 17-nucleotide (nt) and 21-nt sequences in the 5′ UTR of human enteroviruses and rhinoviruses constitute a predicted pseudoknot that is significantly more stable than those that can be formed from a large set of randomly shuffled sequences. A conserved single-stranded polypyrimidine tract is located between two conserved tertiary elements. R. Nicholson, J. Pelletier, S.-Y. Le, and N. Sonenberg (1991, J. Virol. 65, 5886–5894) demonstrated that the point mutations of 3-nt UUU out of an essential 4-nt pyrimidine stretch sequence UUUC abolished translation. Structural analysis of the mutant sequence indicates that small point mutations within the short polypyrimidine sequence would destroy the tertiary interaction in the predicted, highly ordered structure. The proposed common tertiary structure can offer experimentalists a model upon which to extend the interpretations for currently available data. Based on these structural features possible base-pairing models between human enteroviruses and 18 S rRNA and between human rhinoviruses and 18 S rRNA are proposed. The proposed common structure implicates a biological function for these sequences in translational initiation.
has issue date	1992-12-31(xsd:dateTime)
bibo:doi	10.1016/0042-6822(92)90261-m
bibo:pmid	1333125
has license	els-covid
sha1sum (hex)	b2c3d23447ffc0764c2105b7e0d874b992e29513
schema:url	https://doi.org/10.1016/0042-6822%2892%2990261-m
resource representing a document's title	Conserved tertiary structure elements in the 5′ untranslated region of human enteroviruses and rhinoviruses
has PubMed Central identifier	PMC7131026
has PubMed identifier	1333125
schema:publication	Virology
resource representing a document's body	covid:b2c3d23447ffc0764c2105b7e0d874b992e29513#body_text
is schema:about of	named entity 'thermodynamic' named entity 'binding' named entity 'landing pad' named entity 'comparative' named entity 'Untranslated Region' named entity 'Conserved' named entity 'TERTIARY STRUCTURE' named entity 'RIBOSOME BINDING' named entity 'COMMON' named entity 'RHINOVIRUSES' named entity 'COMPARATIVE SEQUENCE ANALYSIS' named entity 'CONSERVATION' covid:arg/b2c3d23447ffc0764c2105b7e0d874b992e29513 named entity 'UNTRANSLATED REGION' named entity 'END' named entity 'ELEMENTS' named entity 'ENTEROVIRUSES' named entity 'RHINOVIRUSES' named entity 'ELEMENTS' named entity 'STRUCTURAL' named entity 'METHODS' named entity 'ENTEROVIRUSES' named entity 'HUMAN' named entity 'CONSERVED' named entity 'COMBINATION' named entity 'POLIOVIRUSES' named entity 'HUMAN' named entity 'OCCUR' named entity 'REVEALS' named entity 'LANDING' named entity 'SEGMENT' named entity 'PAD' named entity 'INTERNAL' named entity 'TERTIARY STRUCTURE' named entity 'CRITICAL' named entity 'THERMODYNAMIC' named entity 'UNTRANSLATED REGION' named entity 'PREDICTED' named entity 'RLP' named entity 'enteroviruses' named entity 'Human' named entity 'polioviruses' named entity '3' end' named entity 'tertiary structure' named entity 'ribosome' named entity 'comparative sequence analysis' named entity 'Enteroviruses' named entity 'poliovirus' named entity '5' UTR' named entity 'steric' named entity 'RNA molecules' named entity '5' UTR' named entity 'Shine-Dalgarno sequence' named entity 'pyrimidine' named entity 'sequence data' named entity 'mRNAs' named entity 'protein expression' named entity 'enteroviruses' named entity 'multiple alignment' named entity 'Fortran' named entity 'tertiary structure' named entity 'tertiary structure' named entity 'picornaviruses' named entity 'pseudoknot' named entity 'pseudoknot' named entity 'pseudoknot' named entity 'pseudoknot' named entity 'pseudoknot' named entity 'polioviruses' named entity 'tertiary structural' named entity 'statistically significant' named entity 'pseudoknot' named entity 'tertiary structure' named entity '3'-end' named entity '5' cap structure' named entity 'CB4' named entity 'tertiary interactions' named entity 'tertiary structure'

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