About: Pathogenicity of porcine G9P[23] and G9P[7] rotaviruses in piglets

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About: Pathogenicity of porcine G9P[23] and G9P[7] rotaviruses in piglets Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Pathogenicity of porcine G9P[23] and G9P[7] rotaviruses in piglets
Creator	Cho, Kyoung-Oh Kang, Mun-Il Kim, Ha-Hyun Park, Su-Jin Yang, Dong-Kun Kim, Hyun-Jeong Matthijnssens, Jelle Kim, Deok-Song Kwon, Hyung-Jun Lee, Ju-Hwan Park, Jun-Gyu Ryu, Eun-Hye Son, Kyu-Yeol Lee, Woo
Source	Elsevier; Medline; PMC
abstract	G9 group A rotaviruses (RVAs) are considered important pathogens in pigs and humans, and pigs are hypothesized to be a potential host reservoir for human. However, intestinal and extra-intestinal pathogenicity and viremia of porcine G9 RVAs has remained largely unreported. In this study, colostrum-deprived piglets were orally infected with a porcine G9P[23] or G9P[7] strain. Histopathologically, both strains induced characteristic small intestinal lesions. Degeneration and necrosis of parenchymal cells were observed in the extra-intestinal tissues, but most predominantly in the mesenteric lymph nodes (MLNs). RVA antigen was continuously detected in the small intestinal mucosa and MLNs, but only transiently in cells of the liver, lung, and choroid plexus. Viral RNA levels were much higher in the feces and the MLNs compared to other tissues. The onset of viremia occurred at day post infection (DPI) 1 with the amount of viral RNA reaching its peak at DPI 3 or 5, before decreasing significantly at DPI 7 and remaining detectable until DPI 14. Our data suggest that porcine G9 RVAs have a strong small intestinal tropism, are highly virulent for piglets, have the ability to escape the small intestine, spread systemically via viremia, and replicate in extra-intestinal tissues. In addition, MLNs might act as a secondary site for viral amplification and the portal of systemic entry. These results add to our understanding of the pathogenesis of human G9 RVAs, and the validity of the pig model for use with both human and pig G9 RVAs in further studies.
has issue date	2013-09-27(xsd:dateTime)
bibo:doi	10.1016/j.vetmic.2013.05.024
bibo:pmid	23827353
has license	no-cc
sha1sum (hex)	b2bdc5d35705dcbcbf7940b7398c21b228c22e1f
schema:url	https://doi.org/10.1016/j.vetmic.2013.05.024
resource representing a document's title	Pathogenicity of porcine G9P[23] and G9P[7] rotaviruses in piglets
has PubMed Central identifier	PMC7117468
has PubMed identifier	23827353
schema:publication	Vet Microbiol
resource representing a document's body	covid:b2bdc5d35705dcbcbf7940b7398c21b228c22e1f#body_text
is schema:about of	named entity 'PORCINE' named entity 'G9P' named entity 'PATHOGENICITY' named entity 'ROTAVIRUSES' named entity 'vaccines' named entity 'enterocytes' named entity 'porcine' named entity 'RNA' named entity 'virus' named entity 'regression analysis' named entity '3.5' named entity 'intestines' named entity 'villous' named entity 'villous' named entity 'genotype' named entity 'viral RNA' named entity 'infection' named entity 'lamina propria' named entity 'small intestinal' named entity 'serum' named entity 'antigen-presenting cells' named entity 'nasal swab' named entity 'antigen' named entity 'Jain' named entity 'RT-PCR' named entity 'VP6' named entity 'porcine' named entity 'genotype' named entity 'cloned' named entity 'antigen' named entity 'Histopathologically' named entity 'piglet' named entity 'liver' named entity 'assay' named entity 'PBS' named entity 'spleen' named entity 'porcine' named entity 'PBS' named entity 'porcine' named entity 'pathogens' named entity 'supernatant' named entity 'atrophy' named entity 'virus' named entity 'genotype' named entity 'feces' named entity 'villous atrophy' named entity 'SYBR Green' named entity 'porcine' named entity 'lymphoid cells' named entity 'tropism' named entity 'choroid plexus' named entity 'Reverse transcription' named entity 'young children' named entity 'virus' named entity 'porcine' named entity 'interspecies transmission' named entity 'Inoculation' named entity 'epithelium' named entity 'animal species' named entity 'public health' named entity 'tropism' named entity 'small intestine' named entity 'interstitial pneumonia' named entity 'genome' named entity 'antigen' named entity 'viremia' named entity 'genome' named entity 'diarrhea'

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