About: Genotypic and phenotypic characterization of the California 99 (Cal99) variant of infectious bronchitis virus

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Genotypic and phenotypic characterization of the California 99 (Cal99) variant of infectious bronchitis virus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Genotypic and phenotypic characterization of the California 99 (Cal99) variant of infectious bronchitis virus
Creator	Cardona, Carol Ae, Shankar Cardona, Ae Mondal, S
Source	Medline; PMC
abstract	The California 99 (Cal99) variant of infectious bronchitis virus (IBV) was first recovered in 1999 from vaccinated broiler chicken flocks in Central California. The S1 hypervariable region of Cal99 genome was most closely related to Arkansas (Ark) serotype viruses. In this study, the complete genome of Cal99 was sequenced, and the structural protein genes were compared with those of commonly used IBV vaccines as well as those of isolates from naturally occurring outbreaks in different parts of the world, to elucidate potential sources of genetic material. Based on sequence comparison, the prototype Cal99 virus is similar to the apathogenic ArkDPI virus, except in the S1 gene and stretches of sequence in the S2 and M structural protein genes, which are more related to Connecticut (Conn) and Massachusetts (Mass) strain viruses, respectively. We speculate that these two fragments came from a Conn and a Mass virus, respectively, and were incorporated into a virus largely derived from ArkDPI. Since Ark, Conn and Mass strains have been simultaneously used as live vaccines in California, both point mutations and recombination among vaccine strains may have contributed to the emergence of the Cal99 variant virus. Analysis of the structural protein genes of six Cal99 isolates demonstrated that viruses of this serotype may differ substantially in the non-S1 structural genes. Finally, we performed a challenge study with Cal99 and demonstrated that the virus causes late-onset respiratory disease, with a severity comparable to that of the M41 IBV challenge strain.
has issue date	2007-06-01(xsd:dateTime)
bibo:doi	10.1007/s11262-006-0014-7
bibo:pmid	16927130
has license	no-cc
sha1sum (hex)	b206a0c8b14d68cd814c5727806018480d162392
schema:url	https://doi.org/10.1007/s11262-006-0014-7
resource representing a document's title	Genotypic and phenotypic characterization of the California 99 (Cal99) variant of infectious bronchitis virus
has PubMed Central identifier	PMC7088715
has PubMed identifier	16927130
schema:publication	Virus Genes
resource representing a document's body	covid:b206a0c8b14d68cd814c5727806018480d162392#body_text
is schema:about of	named entity 'speculate' named entity 'demonstrated' named entity 'prototype' covid:arg/b206a0c8b14d68cd814c5727806018480d162392 named entity 'respiratory disease' named entity 'gene' named entity '1999' named entity 'viruses' named entity 'virus' named entity 'sequence' named entity 'parts' named entity 'vaccines' named entity 'serotype' named entity 'live vaccines' named entity 'Ark' named entity 'Mass' named entity 'phenotypic' named entity 'serotype' named entity 'Arkansas' named entity 'virus' named entity 'IBV' named entity 'viruses' named entity 'IBV' named entity 'protein' named entity 'Vector NTI' named entity 'serology' named entity 'Central California' named entity 'pathogen' named entity 'poultry' named entity 'viral pathogenesis' named entity 'recombination' named entity 'virus' named entity 'highly contagious' named entity 'protein' named entity 'neutralizing antibodies' named entity 'lung parenchyma' named entity 'structural protein' named entity 'genetic similarity' named entity 'nasal discharge' named entity 'pathogenic viruses' named entity 'nucleotide' named entity 'antigenic' named entity 'monoclonal antibodies' named entity 'E. coli' named entity 'RNA' named entity 'negative control' named entity 'IBVs' named entity 'clinical signs' named entity 'protein' named entity 'protein' named entity 'universal primers' named entity 'IBV' named entity 'gene' named entity 'co-infected' named entity 'sequence similarity' named entity 'gene' named entity 'IBV' named entity 'conserved regions' named entity 'gene' named entity 'IBV' named entity 'broiler chicken' named entity 'vaccine' named entity 'IBVs' named entity 'virus' named entity 'viruses' named entity 'virus' named entity 'gene' named entity 'virus' named entity 'H52' named entity 'serotype' named entity 'virus' named entity 'genetic modifications' named entity 'clones' named entity 'gene' named entity 'gene' named entity 'virus' named entity 'diagnostic tests' named entity 'live vaccines'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software