About: Human adenovirus replication and persistence in hypertrophic adenoids and palatine tonsils in children

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Human adenovirus replication and persistence in hypertrophic adenoids and palatine tonsils in children Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Human adenovirus replication and persistence in hypertrophic adenoids and palatine tonsils in children
Creator	Silva, Maria Marciel De Souza, William Luiz Proenca-Modena, José Anselmo-Lima, Terezinha Bertol, Wildgrube Bruna, \| Buzatto, Pietrucci Criado, Ferreira Demarco, Cassiano Eurico Arruda, \| Fabiana, \| Guilherme, \| Jéssica, \| Mirela, \| Miriã, \| Paier Milanez, Guilherme Parise, Lorencini Pereira, Cardoso Pierina, \| Prates, Cristina Ricardo De Souza Cardoso, \| Ricardo, \| Santos De Jesus, Lais Tamashiro, \| Wilma, \|
Source	Medline; PMC
abstract	The role of human adenovirus (HAdV) infection in different acute diseases, such as febrile exudative tonsillitis, conjunctivitis, and pharyngoconjunctival fever is well established. However, the relationships, if any, of HAdV persistence and reactivation in the development of the chronic adenotonsillar disease is not fully understood. The present paper reports a 3‐year cross‐sectional hospital‐based study aimed at detecting and quantifying HAdV DNA and mRNA of the HAdV hexon gene in adenoid and palatine tonsil tissues and nasopharyngeal secretions (NPS) from patients with adenotonsillar hypertrophy or recurrent adenotonsillitis. HAdV C, B, and E were detectable in nearly 50% of the patients, with no association with the severity of airway obstruction, nor with the presence of recurrent tonsillitis, sleep apnea or otitis media with effusion (OME). Despite the higher rates of respiratory viral coinfections in patients with HAdV, the presence of other viruses, including DNA and RNA viruses, had no association with HAdV replication or shedding in secretions. Higher HAdV loads in adenoids showed a significant positive correlation with the presence of sleep apnea and the absence of OME. Although this study indicates that a significant proportion (~85%) of individuals with chronic adenotonsillar diseases have persistent nonproductive HAdV infection, including those by HAdV C, B, and E, epithelial and subepithelial cells in tonsils seem to be critical for HAdV C production and shedding in NPS in some patients, since viral antigen was detected in these regions by immunohistochemistry in four patients, all of which were also positive for HAdV mRNA detection.
has issue date	2019-03-18(xsd:dateTime)
bibo:doi	10.1002/jmv.25441
bibo:pmid	30815882
has license	no-cc
sha1sum (hex)	b2008305cb68fdc84d5bfec8215b00a09c0e6ced
schema:url	https://doi.org/10.1002/jmv.25441
resource representing a document's title	Human adenovirus replication and persistence in hypertrophic adenoids and palatine tonsils in children
has PubMed Central identifier	PMC7166372
has PubMed identifier	30815882
schema:publication	J Med Virol
resource representing a document's body	covid:b2008305cb68fdc84d5bfec8215b00a09c0e6ced#body_text
is schema:about of	named entity 'individuals' named entity 'epithelial' named entity 'exudative' named entity 'detectable' covid:arg/b2008305cb68fdc84d5bfec8215b00a09c0e6ced named entity 'Despite' named entity 'disease' named entity 'presence' named entity 'secretions' named entity 'detection' named entity 'tonsillitis' named entity 'antigen' named entity 'effusion' named entity 'febrile' named entity 'diseases' named entity 'gene' named entity 'infection' named entity 'positive' named entity 'human' named entity 'cross-sectional' named entity 'tonsillitis' named entity 'secretions' named entity 'OME' named entity 'tonsillitis' named entity 'coinfections' named entity 'tonsillitis' named entity 'conjunctivitis' named entity 'mRNA' named entity 'epithelial' named entity 'DNA and RNA' named entity 'palatine tonsil' named entity 'sleep apnea' named entity 'hexon' named entity 'palatine tonsils' named entity 'adenovirus' named entity 'genus' named entity 'viruses' named entity 'infection' named entity 'tonsils' named entity 'real-time PCR' named entity 'Streptococcus pneumoniae' named entity 'lymphocytes' named entity 'adenoids' named entity 'phylogenetic tree' named entity 'serotypes' named entity 'adenoids' named entity 'obese' named entity 'tonsils' named entity 'adenoids' named entity 'tonsils' named entity 'real-time PCR' named entity 'obstructive sleep apnea' named entity 'best-fit' named entity 'sleep apnea' named entity 'asymptomatic' named entity 'MAFFT' named entity 'hexon'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software