About: Isolation and experimental inoculation of an S INDEL strain of porcine epidemic diarrhea virus in Japan

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About: Isolation and experimental inoculation of an S INDEL strain of porcine epidemic diarrhea virus in Japan Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Isolation and experimental inoculation of an S INDEL strain of porcine epidemic diarrhea virus in Japan
Creator	Nakanishi, Makoto Niinuma, Shingo Soma, Junichi Yamaguchi, Ryosaku Yamamoto, Ryuichi
Source	Elsevier; Medline; PMC
abstract	Abstract In 2013, porcine epidemic diarrhea (PED) was reported in Japan for the first time in 7years and caused significant economic losses. In the present study, we isolated PED virus (PEDV) circulating in Japan using Vero cell cultures and analyzed sequences of S1 genes of these PEDV isolates. Sequence analysis revealed that one of these strains contained distinct insertion and deletions in the S gene (i.e., S INDEL). Furthermore, inoculation of PEDV into 1-week-old pigs demonstrated that the S INDEL strain had a lower pathogenicity than the North American (NA) prototype strain. This is the first report comparing pathogenicity of an S INDEL strain with the NA prototype strain following experimental inoculation. Excretion of PEDV in the feces of S INDEL strain-inoculated pigs occurred later than in NA prototype strain-inoculated pigs. Thus, our findings suggested that the S INDEL strain had different viral dynamics than the NA prototype strain.
has issue date	2015-12-31(xsd:dateTime)
bibo:doi	10.1016/j.rvsc.2015.09.024
bibo:pmid	26679803
has license	els-covid
sha1sum (hex)	b1f6e102b07909f9517560f96460e8f1195a3305
schema:url	https://doi.org/10.1016/j.rvsc.2015.09.024
resource representing a document's title	Isolation and experimental inoculation of an S INDEL strain of porcine epidemic diarrhea virus in Japan
has PubMed Central identifier	PMC7173067
has PubMed identifier	26679803
schema:publication	Research in Veterinary Science
resource representing a document's body	covid:b1f6e102b07909f9517560f96460e8f1195a3305#body_text
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