About: Vaccinia and Pox-Virus

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Vaccinia and Pox-Virus
Creator	Bartlett, David Chalikonda, Sricharan Hunt, K Swisher, S Vorburger, S
Source	PMC
abstract	Vaccinia virus has been studied extensively since its discovery as a smallpox vaccine in 1798. Its use as a smallpox vaccine documented its safety profile. It was later found that its large size and ability to accept large fragments of DNA combined with its natural tumor affinity make it an attractive agent for cancer therapy. This chapter discusses the history of the vaccinia, the various strains available, the biology of the virus as well as the steps in creating recombinants. The various clinical and safety considerations will be addressed. We will also discuss the various methods used to treat cancer using the vaccinia virus and will review the recent clinical trials using vaccinia in the treatment of cancer.
has issue date	2007-01-01(xsd:dateTime)
bibo:doi	10.1007/978-1-59745-222-9_4
has license	no-cc
sha1sum (hex)	b1797c0dcef4d1f3306c45e2abb239b148027ab4
schema:url	https://doi.org/10.1007/978-1-59745-222-9_4
resource representing a document's title	Vaccinia and Pox-Virus
has PubMed Central identifier	PMC7123383
schema:publication	Gene Therapy for Cancer
resource representing a document's body	covid:b1797c0dcef4d1f3306c45e2abb239b148027ab4#body_text
is schema:about of	named entity 'large' named entity 'safety' named entity 'FOR' named entity 'tumor' named entity 'size' named entity 'affinity' named entity 'DNA' named entity 'RESPONSE' named entity 'safety profile' named entity 'smallpox vaccine' named entity 'TUMOR' named entity 'RECOMBINANT' named entity 'VACCINIA' named entity 'Vaccinia' named entity 'natural' named entity 'brain tissue' named entity 'locus' named entity 'cervical cancer' named entity 'vaccinia' named entity 'protein' named entity 'intradermally' named entity 'phase II clinical trial' named entity 'IL-18' named entity 'plasmid' named entity 'phase I clinical trial' named entity 'knockout mice' named entity 'nude mice' named entity 'virus' named entity 'viral protein' named entity 'mice' named entity 'eczematous' named entity 'CEA' named entity 'cellular membranes' named entity 'polymerase' named entity 'viruses' named entity 'virus' named entity 'PSA' named entity 'Th1' named entity 'cytoplasm' named entity 'ScFv' named entity 'vector' named entity 'Vaccinia' named entity 'viral replication' named entity 'family of viruses' named entity 'vaccinia virus' named entity 'tumor' named entity 'GM-CSF' named entity 'virus' named entity 'antibody' named entity 'vaccinia' named entity 'infection' named entity 'virus' named entity 'virus' named entity 'p53' named entity 'vaccinia virus' named entity 'PSA' named entity 'Viral surface proteins' named entity 'tumors' named entity 'viral load' named entity 'DNA sequences' named entity 'immunostimulatory' named entity 'vaccinia' named entity 'phase I clinical trial' named entity 'vaccinia' named entity 'gene expression' named entity 'vaccinia virus' named entity 'vaccinia' named entity 'transcription' named entity 'Homologous recombination' named entity 'interferon' named entity 'eradication of smallpox' named entity 'homologous recombination' named entity 'CEA' named entity 'IL-4' named entity 'encephalitis' named entity 'recombinant' named entity 'Vaccinia virus' named entity 'tumor cells' named entity 'ulcer'

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