About: SARS-CoV-2 transmission and control in a hospital setting: an individual-based modelling study

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	SARS-CoV-2 transmission and control in a hospital setting: an individual-based modelling study
Creator	Wang, Xuan Fu, ; Mary, ; Gurarie, David Horn, Ann Huang, Qimin Jiang, Xiaobing Martial Ndeffo-Mbah, ; Mondal, Anirban Zhao, Hongyang Fan, Fei, ;
Source	MedRxiv
abstract	Background: Development of strategies for mitigating the severity of COVID-19 is now a top global public health priority. We sought to assess strategies for mitigating the COVID-19 outbreak in a hospital setting via the use of non-pharmaceutical interventions such as social distancing, self-isolation, tracing and quarantine, wearing facial masks/ personal protective equipment. Methods: We developed an individual-based model for COVID-19 transmission among healthcare workers in a hospital setting. We calibrated the model using data of a COVID-19 outbreak in a hospital unit in Wuhan in a Bayesian framework. The calibrated model was used to simulate different intervention scenarios and estimate the impact of different interventions on outbreak size and workday loss. Results: We estimated that work-related stress increases susceptibility to COVID-19 infection among healthcare workers by 52% (90% Credible Interval (CrI): 16.4% - 93.0%). The use of high efficacy facial masks was shown to be able to reduce infection cases and workday loss by 80% (90% CrI: 73.1% - 85.7%) and 87% (CrI: 80.0% - 92.5%), respectively. The use of social distancing alone, through reduced contacts between healthcare workers, had a marginal impact on the outbreak. A strict quarantine policy with the isolation of symptomatic cases and a high fraction of pre-symptomatic/ asymptomatic cases (via contact tracing or high test rate), could only prolong outbreak duration with minimal impact on the outbreak size. Our results indicated that a quarantine policy should be coupled with other interventions to achieve its effect. The effectiveness of all these interventions was shown to increase with their early implementation. Conclusions: Our analysis shows that a COVID-19 outbreak in a hospital's non-COVID-19 unit can be controlled or mitigated by the use of existing non-pharmaceutical measures.
has issue date	2020-08-25(xsd:dateTime)
bibo:doi	10.1101/2020.08.22.20179929
has license	medrxiv
sha1sum (hex)	b0fd71656983c4d43f85814460271a29cf1bb9ea
schema:url	https://doi.org/10.1101/2020.08.22.20179929
resource representing a document's title	SARS-CoV-2 transmission and control in a hospital setting: an individual-based modelling study
resource representing a document's body	covid:b0fd71656983c4d43f85814460271a29cf1bb9ea#body_text
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