About: Utilization of human DC-SIGN and L-SIGN for entry and infection of host cells by the New World arenavirus, Junín virus

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About: Utilization of human DC-SIGN and L-SIGN for entry and infection of host cells by the New World arenavirus, Junín virus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Utilization of human DC-SIGN and L-SIGN for entry and infection of host cells by the New World arenavirus, Junín virus
Creator	Belouzard, Sandrine Candurra, Nélida Whittaker, Gary Cordo, Guadalupe Martinez, M
Source	Elsevier; Medline; PMC
abstract	The target cell tropism of enveloped viruses is regulated by interactions between viral proteins and cellular receptors determining susceptibility at a host cell, tissue or species level. However, a number of additional cell-surface moieties can also bind viral envelope glycoproteins and could act as capture receptors, serving as attachment factors to concentrate virus particles on the cell surface, or to disseminate the virus infection to target organs or susceptible cells within the host. Here, we used Junín virus (JUNV) or JUNV glycoprotein complex (GPC)-pseudotyped particles to study their ability to be internalized by the human C-type lectins hDC- or hL-SIGN. Our results provide evidence that hDC- and hL-SIGN can mediate the entry of Junín virus into cells, and may play an important role in virus infection and dissemination in the host.
has issue date	2013-11-01(xsd:dateTime)
bibo:doi	10.1016/j.bbrc.2013.10.106
bibo:pmid	24183720
has license	green-oa
sha1sum (hex)	b0f37afb708c688423597184e2e3cb240c4aed89
schema:url	https://doi.org/10.1016/j.bbrc.2013.10.106
resource representing a document's title	Utilization of human DC-SIGN and L-SIGN for entry and infection of host cells by the New World arenavirus, Junín virus
has PubMed Central identifier	PMC4096786
has PubMed identifier	24183720
schema:publication	Biochemical and Biophysical Research Communications
resource representing a document's body	covid:b0f37afb708c688423597184e2e3cb240c4aed89#body_text
is schema:about of	named entity 'NEW WORLD ARENAVIRUS' named entity 'particles' named entity 'internalized' named entity 'ADN' named entity 'ACT' named entity 'HOST' named entity 'HUMAN' named entity 'PROVIDE' named entity 'GLYCOPROTEINS' named entity 'RESULTS' named entity 'GLYCOPROTEIN COMPLEX' named entity 'JUN' named entity 'ENTRY' named entity 'CELLS' named entity 'HERE' named entity 'HUMAN' named entity 'CONCENTRATE' named entity 'RECEPTORS' named entity 'SERVING' named entity 'ATTACHMENT' named entity 'L-SIGN' named entity 'DC-SIGN' named entity 'LECTINS' named entity 'BIND' named entity 'HOST CELLS' named entity 'DISSEMINATE' named entity 'PARTICLES' named entity 'TARGET' named entity 'VIRUSES' named entity 'ORGANS' named entity 'TISSUE' named entity 'TARGET CELL' named entity 'VIRUS' named entity 'ADDITIONAL' named entity 'VIRAL ENVELOPE' named entity 'NUMBER OF' named entity 'SURFACE' named entity 'ROLE' named entity 'MEDIATE' named entity 'THEIR' named entity 'SIGN' named entity 'TYPE' named entity 'REGULATED' named entity 'VIRUS INFECTION' named entity 'CAPTURE' named entity 'INTERACTIONS' named entity 'STUDY' named entity 'IMPORTANT' named entity 'PLAY' named entity 'EVIDENCE' named entity 'TROPISM' named entity 'SUSCEPTIBLE' named entity 'OUR' named entity 'LEVEL' named entity 'CELL SURFACE' named entity 'CELL' named entity 'VIRUS PARTICLES' named entity 'SPECIES' named entity 'SUSCEPTIBILITY' named entity 'CELLULAR' named entity 'VIRAL PROTEINS' named entity 'UTILIZATION' named entity 'VIRUS' named entity 'USED' named entity 'HOST CELL' named entity 'DISSEMINATION' named entity 'ENTRY' named entity 'INFECTION' named entity 'JUN' named entity 'ADN' named entity 'provide' named entity 'mediate' named entity 'tissue' named entity 'C-type' named entity 'However' named entity 'virus' named entity 'cells'

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