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  • Intramuscular dosing of 32 ChAd - SARS - CoV - 2 - S induces robust systemic humoral and cell - mediated immune responses 33 and protects against lung infection , inflammation , and pathology but does not confer sterilizing 34 immunity , as evidenced by detection of viral RNA and induction of anti - nucleoprotein antibodies 35 after SARS - CoV - 2 challenge .
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