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  • In SARS - or MERS - CoV infected mice , both prophylactic 76 and therapeutic administration EIDD - 2801 , an oral NHC - prodrug ( b - D - N 4 - 77 hydroxycytidine - 5 ' - isopropyl ester ) improved pulmonary function and reduced virus titer 78 and ameliorated disease severity .
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