The %22 after %22 period was associated with a lower risk of death ( HR 0 . 47 ; 95 % CI , 0 . 23 - 0 . 97 ; p = 0 . 04 ) , and a lower risk of intensive care admission or death before ICU admission ( HR 0 . 37 95 % CI 0 . 21 - 0 . 64 ; p = 0 . 0005 ) by multivariate analysis adjusted