About: Pulmonary and cardiac pathology in African American patients with COVID-19: an autopsy series from New Orleans

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About: Pulmonary and cardiac pathology in African American patients with COVID-19: an autopsy series from New Orleans Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Pulmonary and cardiac pathology in African American patients with COVID-19: an autopsy series from New Orleans
Creator	Li, Guang Akmatbekov, Aibek Fox, Sharon Harbert, Jack Akmatbekov, A Brown, Quincy Fox, ( Harbert, J Md, Heide Vader, Richard Vander, R Vander, Richard
Source	Elsevier; Medline; PMC
abstract	BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spread rapidly across the USA, causing extensive morbidity and mortality, particularly in the African American community. Autopsy can considerably contribute to our understanding of many disease processes and could provide crucial information to guide management of patients with coronavirus disease 2019 (COVID-19). We report on the relevant cardiopulmonary findings in, to our knowledge, the first autopsy series of ten African American decedents, with the cause of death attributed to COVID-19. METHODS: Autopsies were performed on ten African American decedents aged 44–78 years with cause of death attributed to COVID-19, reflective of the dominant demographic of deaths following COVID-19 diagnosis in New Orleans. Autopsies were done with consent of the decedents' next of kin. Pulmonary and cardiac features were examined, with relevant immunostains to characterise the inflammatory response, and RNA labelling and electron microscopy on representative sections. FINDINGS: Important findings include the presence of thrombosis and microangiopathy in the small vessels and capillaries of the lungs, with associated haemorrhage, that significantly contributed to death. Features of diffuse alveolar damage, including hyaline membranes, were present, even in patients who had not been ventilated. Cardiac findings included individual cell necrosis without lymphocytic myocarditis. There was no evidence of secondary pulmonary infection by microorganisms. INTERPRETATION: We identify key pathological states, including thrombotic and microangiopathic pathology in the lungs, that contributed to death in patients with severe COVID-19 and decompensation in this demographic. Management of these patients should include treatment to target these pathological mechanisms. FUNDING: None.
has issue date	2020-05-27(xsd:dateTime)
bibo:doi	10.1016/s2213-2600(20)30243-5
bibo:pmid	32473124
has license	no-cc
sha1sum (hex)	af9133930d0dc3c5ccf7dae3d2af90ff839cf452
schema:url	https://doi.org/10.1016/s2213-2600%2820%2930243-5
resource representing a document's title	Pulmonary and cardiac pathology in African American patients with COVID-19: an autopsy series from New Orleans
has PubMed Central identifier	PMC7255143
has PubMed identifier	32473124
schema:publication	Lancet Respir Med
resource representing a document's body	covid:af9133930d0dc3c5ccf7dae3d2af90ff839cf452#body_text
is schema:about of	named entity 'management' named entity 'disease' named entity 'COVID-19' named entity 'DISEASE' named entity 'COMMUNITY' named entity 'NEW ORLEANS' named entity 'ARTICLES' named entity 'SERIES' named entity 'AFRICAN AMERICAN' named entity 'African American' named entity 'causing' named entity 'series' named entity 'Autopsy' named entity 'COVID-19' named entity 'coronavirus disease 2019' named entity 'histology' named entity 'fibrin' named entity 'thrombi' named entity 'New Orleans' named entity 'lungs' named entity 'demographic' named entity 'Thrombi' named entity 'fulminant' named entity 'CD4' named entity 'immunostains' named entity 'cytoplasm' named entity 'infection' named entity 'Europe' named entity 'coronavirus' named entity 'lung' named entity 'liver' named entity 'cough' named entity 'brain natriuretic peptide' named entity 'lymphopenia' named entity 'neutrophil extracellular traps' named entity 'necrosis' named entity 'CD8 +' named entity 'lungs' named entity 'hyaline' named entity 'troponin' named entity 'myocarditis' named entity 'COVID-19' named entity 'spleen' named entity 'lymphopenia' named entity 'necrosis' named entity 'COVID-19' named entity 'platelets' named entity 'African American' named entity 'lungs' named entity 'thromboemboli' named entity 'megakaryocytes' named entity 'fungal infection' named entity 'lungs' named entity 'fibrin' named entity 'bronchi' named entity 'coronary artery' named entity 'small vessels' named entity 'Louisiana State University Health Sciences Center' named entity 'coagulative' named entity 'Chest x-rays' named entity 'macrophage' named entity 'coronary arteries' named entity 'H1N1' named entity 'haemorrhage' named entity 'D-dimer' named entity 'autopsy' named entity 'microangiopathic' named entity 'autopsy' named entity 'neutrophilic' named entity 'COVID'

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