About: Ability of device to collect bacteria from cough aerosols generated by adults with cystic fibrosis

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About: Ability of device to collect bacteria from cough aerosols generated by adults with cystic fibrosis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Ability of device to collect bacteria from cough aerosols generated by adults with cystic fibrosis
Creator	Wolff, Bernard Helfman, Beth Anderson, Larry Ku, David Ku, Sarah Winchell, Jonas Griffith, David Mccarty, Nael Sweden, Karolinska
Source	Medline; PMC
abstract	Background: Identifying lung pathogens and acute spikes in lung counts remain a challenge in the treatment of patients with cystic fibrosis (CF). Bacteria from the deep lung may be sampled from aerosols produced during coughing. Methods: A new device was used to collect and measure bacteria levels from cough aerosols of patients with CF. Sputum and oral specimens were also collected and measured for comparison. Pseudomonas aeruginosa, Staphylococcus aureus, Klebsiella pneumoniae, and Streptococcus mitis were detected in specimens using Real-Time Polymerase Chain Reaction (RT-PCR) molecular assays. Results: Twenty adult patients with CF and 10 healthy controls participated. CF related bacteria (CFRB) were detected in 13/20 (65%) cough specimens versus 15/15 (100%) sputum specimens. Commensal S. mitis was present in 0/17 (0%, p=0.0002) cough specimens and 13/14 (93%) sputum samples. In normal controls, no bacteria were collected in cough specimens but 4/10 (40%) oral specimens were positive for CFRB. Conclusions: Non-invasive cough aerosol collection may detect lower respiratory pathogens in CF patients, with similar specificity and sensitivity to rates detected by BAL, without contamination by oral CFRB or commensal bacteria.
has issue date	2016-08-05(xsd:dateTime)
bibo:doi	10.12688/f1000research.9251.1
bibo:pmid	27781088
has license	cc-by
sha1sum (hex)	af6dacec0a1ba933a47d7451ef69ea06f7029882
schema:url	https://doi.org/10.12688/f1000research.9251.1
resource representing a document's title	Ability of device to collect bacteria from cough aerosols generated by adults with cystic fibrosis
has PubMed Central identifier	PMC5054809
has PubMed identifier	27781088
schema:publication	F1000Res
resource representing a document's body	covid:af6dacec0a1ba933a47d7451ef69ea06f7029882#body_text
is schema:about of	named entity 'Infections' named entity 'lungs' named entity 'specimens' named entity 'Emerson' named entity 'Tract' named entity 'referees' named entity 'PEER REVIEW' covid:arg/af6dacec0a1ba933a47d7451ef69ea06f7029882 named entity 'ROSENFELD' named entity 'CULTURES' named entity 'AIRWAY' named entity 'FREE' named entity 'PUBLISHER' named entity 'TEXT' named entity 'SPECIMENS' named entity 'YOUNG CHILDREN' named entity 'BASED' named entity 'PROC' named entity '1987' named entity 'SAMPLING' named entity 'INFANTS' named entity 'GENERATED' named entity 'ABILITY' named entity 'COUGH' named entity 'BACTERIA ' named entity '762' named entity 'SPUTUM CULTURE' named entity 'MANAGEMENT' named entity 'UPPER' named entity 'LUNG' named entity 'ADULTS' named entity 'PUBMED' named entity 'ABSTRACT' named entity 'AEROSOLS' named entity 'CYSTIC FIBROSIS' named entity 'TO COLLECT' named entity 'OPEN' named entity 'DNA' named entity 'U S A' named entity 'CYSTIC FIBROSIS' named entity 'SCI' named entity 'DIAGNOSTIC ACCURACY' named entity 'APPROVED' named entity 'OROPHARYNGEAL' named entity 'LOWER RESPIRATORY TRACT INFECTIONS' named entity 'ACAD' named entity 'CLIN' named entity 'DIRECT' named entity '328' named entity 'DEVICE' named entity '758' named entity 'MICROBIOTA' named entity 'CYSTIC FIBROSIS LUNGS' named entity '2012' named entity 'Direct' named entity 'cultures' named entity 'PubMed' named entity 'lungs' named entity 'Lower Respiratory Tract Infections' named entity 'cystic fibrosis' named entity 'cystic fibrosis' named entity 'DNA-based' named entity 'young children' named entity 'Open Peer Review' named entity 'bacteria' named entity 'cough' named entity 'microbiology' named entity 'K. pneumoniae' named entity 'bacteria' named entity 'Centers for Disease Control and Prevention' named entity 'cough' named entity 'K. pneumoniae' named entity 'Roche Applied Science'

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